Structure
Seletalisib, Inhibitor
Seletalisib
Purity
>98% (HPLC)
Synonyms
Seletalisib; UCB-5857; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: >=83.3mg/mL
Target
PI3K
Receptor
PI3K
Chemical Name
Pyrido[3, 2-d]pyrimidin-4-amine, N-[(1R)-1-[8-chloro-2-(1-oxido-3-pyridinyl)-3-quinolinyl]-2, 2, 2-trifluoroethyl]
SMILES
FC(F)(F)[C@@H](C1=CC2=CC=CC(Cl)=C2N=C1C3=CC=C[N+]([O-])=C3)NC4=C5C(C=CC=N5)=NC=N4
Molecular Formula
C23H14ClF3N6O
CAS Number
1362850-20-1
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Seletalisib, inhibitor
Seletalisib (UCB-5857) is a potent, ATP-competitive, and selective PI3Kdelta inhibitor with IC50 of 12nM; shows significant selectivity to PI3Kdelta with respect to the other class I PI3K isoforms (204-303 fold); blocks AKT phosphorylation following activation of the B-cell receptor in a B-cell line; blocks human T-cell production of several cytokines from activated T-cells, and inhibits B-cell proliferation and cytokine release; dose-dependently inhibits anti-CD3-antibody-induced interleukin 2 release in mice. Psoriasis Phase 3 Clinical
Product Categories/Family for Seletalisib, inhibitor
References
1. Allen RA, et al. J Pharmacol Exp Ther. 2017 Jun; 361 (3):429-440.
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Product Notes
The Seletalisib (Catalog #AAA3601495) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Seletalisib, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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