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Structure

INCB040093, Inhibitor

INCB040093

Purity
>98% (HPLC)
Synonyms
INCB040093; INCB 040093; INCB-040093; Dezapelisib; inhibitor
Ordering
Purity/Purification
>98% (HPLC)
Target
PI3K
Receptor
PI3K
Chemical Name
6-(3-fluorophenyl)-3-methyl-7-((1S)-1-(9H-purin-6-ylamino)ethyl)-5H-(1, 3)thiazolo(3, 2-a)pyrimidin-5-one
SMILES
O=C1C(C2=CC=CC(F)=C2)=C([C@@H](NC3=C4N=CNC4=NC=N3)C)N=C5N1C(C)=CS5
Molecular Formula
C20H16FN7OS
CAS Number
1262440-25-4
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack

Structure

Structure
Related Product Information for INCB040093, inhibitor
A novel potent, selective, orally available PI3Kdelta inhibitor with IC50 of 31nM; displays 74 to >900-fold selectivity for the other PI3K family members, and does not inhibit a panel of 57 additional kinases; potently inhibits cellular proliferation CD19+ human or CD21+ canine primary B cells with IC50 of 1-3nM, reduces anti-FcR-induced basophil activation in the presence of human whole blood (IC50=33nM); demonstrates promising efficacy in patients with Hodgkin's lymphoma in clinical studies. Blood Cancer Phase 2 Clinical
Product Categories/Family for INCB040093, inhibitor
References
1. Shin N, et al. J Pharmacol Exp Ther. 2017 Nov 10. pii: jpet.117.244947.

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Product Notes

The INCB040093 (Catalog #AAA3601094) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "INCB040093, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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