Molecular Structure
GW-5074, inhibitor
GW-5074
Purity
98% (TLC); NMR (Conforms)
Synonyms
GW-5074; JX-401 ; 1-[2-Methoxy-4-(methylthio)benzoyl]-4-(phenylmethyl)piperidine; 3-(3; 5-Dibromo-4-hydroxy-benzylidene)-5-iodo-1; 3-dihydro-indol-2-one; inhibitor
Purity/Purification
98% (TLC); NMR (Conforms)
Form/Format
Off white powder
CAS Number
220904-83-6
Molecular Formula
C15H8Br2INO2
Melting Point
267-268 degree C
Activity
p38a MAP kinase inhibitor
Reconstitution
May be dissolved in DMSO (20 mg/ml); or Ethanol (10 mg/ml)
Solubilization
May be dissolved in DMSO (50 mg/ml)
Preparation and Storage
Store desiccated as supplied at -20 degree C for up to 2 years. Store solutions at -20 degree C for up to 1 month.
Molecular Structure
Molecular Structure
Related Product Information for GW-5074, inhibitor
c-Raf1 inhibitor
Potent and selective p38 MAP kinase inhibitor XYZ XYZ (IC50=32 nM). Does not inhibit p38 up to 10 M. Inhibition is reversible and noncompetitive with ATP and substrate. Reversibly inhibits myoblast differentiation. Cell permeable.
Scientific Background: Specific inhibitor of cRaf-1 kinase (IC50=9 nM). Acts at >= 100-fold selectivity for raf kinase over CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fm. Displays neuroprotective activity. Cell permeable.
Potent and selective p38 MAP kinase inhibitor XYZ XYZ (IC50=32 nM). Does not inhibit p38 up to 10 M. Inhibition is reversible and noncompetitive with ATP and substrate. Reversibly inhibits myoblast differentiation. Cell permeable.
Scientific Background: Specific inhibitor of cRaf-1 kinase (IC50=9 nM). Acts at >= 100-fold selectivity for raf kinase over CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fm. Displays neuroprotective activity. Cell permeable.
Product Categories/Family for GW-5074, inhibitor
References
1. Y Friedmann et al. Mol. Pharmacol. 2006 70:1395
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Product Notes
The GW-5074 (Catalog #AAA515012) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "GW-5074, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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