Molecular Structure
Dorsomorphin, Inhibitor
Dorsomorphin
Purity
>97% (HPLC); NMR (Conforms)
Synonyms
Dorsomorphin; LYS6K2; 4-(4-(4-(4-fluoro-3-(trifluoromethyl)phenyl)-1-methyl-1H-imidazol-2-yl)piperidin-1-yl)-1H-pyrazolo[3; 4-d]pyrimidine; inhibitor
Purity/Purification
>97% (HPLC); NMR (Conforms)
Form/Format
Yellow solid
CAS Number
866405-64-3
Molecular Formula
C24H25N5O
Melting Point
276-280 degree C
Activity
S6K inhibitor
Reconstitution
May be dissolved in DMSO (1 mg/ml); DMF (3 mg/ml, warm)
Solubilization
May be dissolved in DMSO (4 mg/ml, warm)
Preparation and Storage
Store desiccated as supplied at -20 degree C for up to 1 year. Store solutions at -20 degree C for up to 3 months
Molecular Structure
Molecular Structure
Related Product Information for Dorsomorphin, inhibitor
AMPK inhibitor
A selective inhibitor of the p70 ribosomal S6 kinase (S6K)1. Blocks the phosphorylation of S6 at concentrations as low as 0.1-0.3 M with no activity at GSK3 and Erk1/2 at 10 M2. Useful tool to dissect insulin receptor signaling pathways and was employed to show that the action of mTORC1 on SREB P-1c expression is not mediated by S6K2. Cell permeable.
Scientific Background: A potent, selective and reversible ATP-competitive inhibitor of AMP-activated protein kinase (AMPK), Ki = 109 nM in the presence of ATP and absence of AMP (1). Displays no significant inhibition of JAK3, PKA, PKCtheta, SYK and ZAPK. Suppresses food intake in mice (2) and inhibits the effects of AICAR and metformin (1). It also inhibits BMP type 1 receptors ALK2, ALK3 and ALK6 (3). Promotes cardiomyogenesis in mouse embryonic stem cells (4). Induces autophagy in tumor cell lines via an AMPK-independent pathway (5). Cell permeable.
A selective inhibitor of the p70 ribosomal S6 kinase (S6K)1. Blocks the phosphorylation of S6 at concentrations as low as 0.1-0.3 M with no activity at GSK3 and Erk1/2 at 10 M2. Useful tool to dissect insulin receptor signaling pathways and was employed to show that the action of mTORC1 on SREB P-1c expression is not mediated by S6K2. Cell permeable.
Scientific Background: A potent, selective and reversible ATP-competitive inhibitor of AMP-activated protein kinase (AMPK), Ki = 109 nM in the presence of ATP and absence of AMP (1). Displays no significant inhibition of JAK3, PKA, PKCtheta, SYK and ZAPK. Suppresses food intake in mice (2) and inhibits the effects of AICAR and metformin (1). It also inhibits BMP type 1 receptors ALK2, ALK3 and ALK6 (3). Promotes cardiomyogenesis in mouse embryonic stem cells (4). Induces autophagy in tumor cell lines via an AMPK-independent pathway (5). Cell permeable.
Product Categories/Family for Dorsomorphin, inhibitor
References
1. TR Fenton et al. Int. J. Biochem. Cell Biol. 2011 43:47
2. S Li et al. Proc. Natl. Acad. Sci. USA 2010 107:3441
2. S Li et al. Proc. Natl. Acad. Sci. USA 2010 107:3441
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Product Notes
The Dorsomorphin (Catalog #AAA515055) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Dorsomorphin, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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