Structure
Sapitinib, Inhibitor
Sapitinib
Purity
>98% (HPLC)
Synonyms
Sapitinib; AZD-8931; AZD8931; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: >=33mg/mL
Target
EGFR
Receptor
EGFR; HER2/ErbB2
Chemical Name
1-Piperidineacetamide, 4-[[4-[(3-chloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]oxy]-N-methyl
SMILES
O=C(NC)CN1CCC(OC2=CC3=C(NC4=CC=CC(Cl)=C4F)N=CN=C3C=C2OC)CC1
Molecular Formula
C23H25ClFN5O3
CAS Number
848942-61-0
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Sapitinib, inhibitor
Sapitinib (AZD-8931, AZD8931) is a equipotent, reversible inhibitor of EGFR, ErbB2 and ErbB3 with IC50 of 4. 3 and 4nM (phosphorylation inhibition), respectively; displays >1,000-fold selectivity over a panel of 206 of kinases, >100-fold selectivity for MNK1 and Flt3; AZD8931 is significantly more potent than gefitinib or lapatinib in specific squamous cell carcinoma of the head and neck and non-small cell lung carcinoma cell lines; inhibits xenograft growth in a range of models while significantly affecting EGFR, erbB2, and erbB3 phosphorylation and downstream signaling pathways, apoptosis, and proliferation. Colon Cancer Phase 2 Clinical
Product Categories/Family for Sapitinib, inhibitor
References
1. Hickinson DM, et al. Clin Cancer Res. 2010 Feb 15; 16 (4):1159-69.
2. Singleton KR, et al. Mol Pharmacol. 2013 Apr; 83 (4):882-93.
3. Barlaam B, et al. ACS Med Chem Lett. 2013 May 31; 4 (8):742-6.
4. Mu Z, et al. J Exp Clin Cancer Res. 2014 May 30; 33:47.
2. Singleton KR, et al. Mol Pharmacol. 2013 Apr; 83 (4):882-93.
3. Barlaam B, et al. ACS Med Chem Lett. 2013 May 31; 4 (8):742-6.
4. Mu Z, et al. J Exp Clin Cancer Res. 2014 May 30; 33:47.
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Product Notes
The Sapitinib (Catalog #AAA3606161) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Sapitinib, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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