Structure
Dacomitinib Biochemical
Dacomitinib
Purity
>98% (HPLC)
Synonyms
Dacomitinib; PF-00299804; PF-299804; PF 299804; PF 00299804; Dacomitinib biochemical
Purity/Purification
>98% (HPLC)
Suitability
DMSO: >=50mg/mL (Need ultrasonic)
Target
EGFR
Receptor
EGFR; HER2/ErbB2
Chemical Name
2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-4-(1-piperidinyl)-, (2E)
SMILES
COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)NC(=O)/C=C/CN4CCCCC4
Molecular Formula
C24H25ClFN5O2
CAS Number
1110813-31-4
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Dacomitinib biochemical
Dacomitinib (PF-00299804, PF-299804) is a potent, irreversible, orally active pan-ErbB receptor tyrosine kinase inhibitor with IC50 of 6, 45.7 and 73.7 for EGFR, ERBB2 and ERBB4, respectively; irreversibly inhibits erbB tyrosine kinase activity through binding at the ATP site and covalent modification of nucleophilic cysteine residues in the catalytic domains of erbB family members inhibits erbB1 autophosphorylation in the A431 human squamous cell carcinoma line with IC50 of 15.1nM; causes significant antitumor activity, including marked tumor regressions in a variety of human tumor xenograft models that express and/or overexpress erbB family members or contain the double mutation (L858R/T790M) in EGFR associated with resistance to gefitinib and erlotinib. Lung Cancer Phase 3 Clinical
Product Categories/Family for Dacomitinib biochemical
References
1. Engelman JA, et al. Cancer Res. 2007 Dec 15; 67 (24):11924-32.
2. Gonzales AJ, et al. Mol Cancer Ther. 2008 Jul; 7 (7):1880-9.
3. Nguyen KS, et al. Clin Lung Cancer. 2009 Jul; 10 (4):281-9.
4. Kalous O, et al. Mol Cancer Ther. 2012 Sep; 11 (9):1978-87.
2. Gonzales AJ, et al. Mol Cancer Ther. 2008 Jul; 7 (7):1880-9.
3. Nguyen KS, et al. Clin Lung Cancer. 2009 Jul; 10 (4):281-9.
4. Kalous O, et al. Mol Cancer Ther. 2012 Sep; 11 (9):1978-87.
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Product Notes
The Dacomitinib (Catalog #AAA3600413) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Dacomitinib, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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