Structure
Poziotinib, Inhibitor
Poziotinib
Purity
>98% (HPLC)
Synonyms
Poziotinib; HM781-36B; NOV120101; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
10mM in DMSO
Target
EGFR
Receptor
HER1; HER2; HER4
Chemical Name
2-Propen-1-one, 1-[4-[[4-[(3, 4-dichloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]oxy]-1-piperidinyl]
SMILES
C=CC(N1CCC(OC2=CC3=C(NC4=CC=C(Cl)C(Cl)=C4F)N=CN=C3C=C2OC)CC1)=O
Molecular Formula
C23H21Cl2FN4O3
CAS Number
1092364-38-9
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Poziotinib, inhibitor
Poziotinib (HM781-36B, NOV120101) is an irreversible pan-HER inhibitor with IC50 of 3.2/5.3nM/23.5nM for HER1/HER2/HER4; inhibits phosphorylation of HER family and downstream signaling molecules, and induced apoptosis and G1 arrest; exerts synergistic effects with chemotherapeutic agents. Breast Cancer Phase 2 Clinical
Product Categories/Family for Poziotinib, inhibitor
References
1. Nam HJ, et al. Cancer Lett. 2011 Mar 28; 302 (2):155-65.
2. Cha MY, et al. Int J Cancer. 2012 May 15; 130 (10):2445-54.
3. Kim HJ, et al. Anticancer Drugs. 2012 Mar; 23 (3):288-97.
2. Cha MY, et al. Int J Cancer. 2012 May 15; 130 (10):2445-54.
3. Kim HJ, et al. Anticancer Drugs. 2012 Mar; 23 (3):288-97.
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Product Notes
The Poziotinib (Catalog #AAA3600347) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Poziotinib, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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