Structure
Avitinib, Inhibitor
Avitinib
Purity
>98% (HPLC)
Synonyms
Avitinib; AC-0010; AC0010; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: 88mg/mL (180.5mM) (<1mg/mL refers to the product slightly soluble or insoluble)
Target
EGFR
Receptor
EGFR
Chemical Name
N-[3-[[2-[[3-Fluoro-4-(4-methyl-1-piperazinyl)phenyl]amino]-7H-pyrrolo[2, 3-d]pyrimidin-4-yl]oxy]phenyl]-2-propenamide
SMILES
C=CC(NC1=CC=CC(OC2=C3C(NC=C3)=NC(NC4=CC=C(N5CCN(C)CC5)C(F)=C4)=N2)=C1)=O
Molecular Formula
C26H26FN7O2
CAS Number
1557267-42-1
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Avitinib, inhibitor
Avitinib (AC-0010, AC0010) is an orally available, irreversible, and mutant-selective EGFR inhibitor with IC50 of 0.18nM against EGFR L858R/T790M; displays 43-fold greater potency over wild-type EGFR (IC50=7.68nM); selectively inhibits mutant EGFR phosphorylation (IC50 =7.3nM and 2.8nM) in NCI-H1975 and NIH/3T3_TC32T8 cells, 115- and 298-fold more sensitive than that of the inhibition of wild type EGFR in A431; overcomes T790M-induced resistance in animal models and lung cancer patients without hyperglycemia or other severe adverse effects. Lung Cancer Phase 2 Clinical
Product Categories/Family for Avitinib, inhibitor
References
1. Xu X, et al. Mol Cancer Ther. 2016 Nov; 15 (11):2586-2597.
2. Wang W, et al. J Pharm Biomed Anal. 2017 May 30; 139:205-214.
2. Wang W, et al. J Pharm Biomed Anal. 2017 May 30; 139:205-214.
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Product Notes
The Avitinib (Catalog #AAA3602212) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Avitinib, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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