Structure
Saracatinib, Inhibitor
Saracatinib
Purity
>98% (HPLC)
Synonyms
Saracatinib; AZD0530; AZD-0530; AZD 0530; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: >=32mg/mL
Target
Src
Receptor
BLK; c-Kit; c-Src; c-Yes; EGFR; EGFR (L858R); EGFR (L861Q); EphA2; FGR; Fyn; Lck; Lyn; v-Abl; EGFRL861Q; EGFRL858R
Chemical Name
4-Quinazolinamine, N-(5-chloro-1, 3-benzodioxol-4-yl)-7-[2-(4-methyl-1-piperazinyl)ethoxy]-5-[(tetrahydro-2H-pyran-4-yl)oxy]
SMILES
CN1CCN(CCOC2=CC3=NC=NC(NC4=C5OCOC5=CC=C4Cl)=C3C(OC6CCOCC6)=C2)CC1
Molecular Formula
C27H32ClN5O5
CAS Number
379231-04-6
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Saracatinib, inhibitor
A potent, highly selective, orally available, dual Src/Abl kinase inhibitor with IC50 of 2.7, 4, 4 and 30nM for c-Src, Yes, Lck and Abl, respectively; displays high selectivity over a range of kinases (Csk, VEGFR-2, Flt-4, EGFR, and PDGFR); exhibits potent inhibition of tumor growth in a c-Src-transfected 3T3-fibroblast xenograft model in vivo. Breast Cancer Phase 2 Clinical
Product Categories/Family for Saracatinib, inhibitor
References
1. Hennequin LF, et al. J Med Chem. 2006 Nov 2; 49 (22):6465-88.
2. Herynk MH, et al. Mol Cancer Ther. 2006 Dec; 5 (12):3023-31.
3. Chang YM, et al. Oncogene. 2008 Oct 23; 27 (49):6365-75.
4. Gwanmesia PM, et al. BMC Cancer. 2009 Feb 13; 9:53.
2. Herynk MH, et al. Mol Cancer Ther. 2006 Dec; 5 (12):3023-31.
3. Chang YM, et al. Oncogene. 2008 Oct 23; 27 (49):6365-75.
4. Gwanmesia PM, et al. BMC Cancer. 2009 Feb 13; 9:53.
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Product Notes
The Saracatinib (Catalog #AAA3604307) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Saracatinib, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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