Structure
Lapatinib ditosylate, Inhibitor
Lapatinib ditosylate
Purity
>98% (HPLC)
Synonyms
Lapatinib ditosylate; GW 572016 ditosylate; GW-572016 ditosylate; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
10mM in DMSO
Target
EGFR
Receptor
C-Raf-1; c-Src; EGFR; HER2/ErbB2; ErbB2
Chemical Name
4-Quinazolinamine, N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furanyl]-, 4-methylbenzenesulfonate(1:2)
SMILES
CC1=CC=C(C=C1)S(O)(=O)=O.CC1=CC=C(C=C1)S(O)(=O)=O.CS(=O)(=O)CCNCC1=CC=C(O1)C1=CC2=C(C=C1)N=CN=C2NC1=CC(Cl)=C(OCC2=CC(F)=CC=C2)C=C1
Molecular Formula
C43H42ClFN4O10S3
CAS Number
388082-77-7
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Lapatinib ditosylate, inhibitor
A reversible, selective dual tyrosine kinase inhibitor of both EGFR and ErbB2 with IC50 of 10.8 and 9.2nM in cell-free assays, respectively; displays no significant activity against other kinases, including ErbB4, c-Src, and c-Raf1; reduces tyrosine phosphorylation of EGFR and erbB2, and inhibits activation of Erk1/2 and AKT both in vitro and in vivo; inhibits tumor xenograft growth of the HN5 and BT474 cells in a dose-responsive manner at 30 and 100mg/kg; orally active. Breast Cancer Approved
Product Categories/Family for Lapatinib ditosylate, inhibitor
References
1. Xia W, et al. Oncogene. 2002 Sep 12; 21 (41):6255-63.
2. Rusnak DW, et al. Mol Cancer Ther. 2001 Dec; 1 (2):85-94.
3. Konecny GE, et al. Cancer Res. 2006 Feb 1; 66 (3):1630-9.
2. Rusnak DW, et al. Mol Cancer Ther. 2001 Dec; 1 (2):85-94.
3. Konecny GE, et al. Cancer Res. 2006 Feb 1; 66 (3):1630-9.
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Product Notes
The Lapatinib ditosylate (Catalog #AAA3604334) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Lapatinib ditosylate, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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