Structure
Canertinib dihydrochloride, Inhibitor
Canertinib dihydrochloride
Purity
>98% (HPLC)
Synonyms
Canertinib dihydrochloride; Canertinib; CI-1033 dihydrochloride; PD-183805 dihydrochloride; CI1033 dihydrochloride; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
10mM in DMSO
Target
EGFR
Receptor
EGFR; HER2/ErbB2
Chemical Name
2-Propenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]-6-quinazolinyl]-, hydrochloride(1:2)
SMILES
C=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4.Cl.Cl
Molecular Formula
C24H27Cl3FN5O3
CAS Number
289499-45-2
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Canertinib dihydrochloride, inhibitor
A potent, irreversible, orally available pan-ErbB inhibitor for EGFR and ErbB2 with IC50 of 7.5nM and 9.0nM in autophosphorylation assay; displays no activity to PDGFR, FGFR, InsR, PKC, and CDK1/2/4; suppresses heregulin-stimulated tyrosine phosphorylation of erbB2, erbB3 and erbB4 with IC50 of 5, 14 and 10nM, respectively, also inhibits expression of pp62c-fos in response to heregulin; shows high in vivo activity against A431 xenografts. Lung Cancer Discontinued
Product Categories/Family for Canertinib dihydrochloride, inhibitor
References
1. Smaill JB, et al. J Med Chem. 2000 Apr 6; 43 (7):1380-97.
2. Erlichman C, et al. Cancer Res. 2001 Jan 15; 61 (2):739-48.
3. Nyati MK, et al. Clin Cancer Res. 2004 Jan 15; 10 (2):691-700.
4. Slichenmyer WJ, et al. Semin Oncol. 2001 Oct; 28 (5 Suppl 16):80-5.
2. Erlichman C, et al. Cancer Res. 2001 Jan 15; 61 (2):739-48.
3. Nyati MK, et al. Clin Cancer Res. 2004 Jan 15; 10 (2):691-700.
4. Slichenmyer WJ, et al. Semin Oncol. 2001 Oct; 28 (5 Suppl 16):80-5.
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Product Notes
The Canertinib dihydrochloride (Catalog #AAA3603885) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Canertinib dihydrochloride, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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