Structure
BLU9931, Inhibitor
BLU9931
Purity
>98% (HPLC)
Synonyms
BLU9931; BLU-9931; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: 17mg/mL
Target
FGFR
Receptor
FGFR1; FGFR2; FGFR3; FGFR4
Chemical Name
2-Propenamide, N-[2-[[6-(2, 6-dichloro-3, 5-dimethoxyphenyl)-2-quinazolinyl]amino]-3-methylphenyl]
SMILES
COC1=CC(OC)=C(Cl)C(=C1Cl)C1=CC2=CN=C(NC3=C(C)C=CC=C3NC(=O)C=C)N=C2C=C1
Molecular Formula
C26H22Cl2N4O3
CAS Number
1538604-68-0
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for BLU9931, inhibitor
BLU9931 (BLU-9931) is a potent, selective, irreversible inhibitor of FGFR4 with IC50 of 3nM, shows much weaker activity for FGFR1 (IC50=591nM), FGFR2 (IC50=493nM) and FGFR3 (IC50=150nM); potently and selectively inhibits FGFR4 signaling and cell proliferation in HCC cell lines with an activated FGFR4 signaling pathway (Huh-7 cell IC50=110nM, JHH-7 IC50=20nM); shows remarkable antitumor activity in mice bearing HCC tumor xenograft that overexpresses FGF19. Lung Cancer Phase 1 Clinical
Product Categories/Family for BLU9931, inhibitor
References
1. Hagel M, et al. Cancer Discov. 2015 Apr; 5 (4):424-37.
2. Packer LM, et al. Cancer Discov. 2015 Apr; 5 (4):355-7.
3. Yamamoto M, et al. Cancer Sci. 2018 Mar 13. doi: 10.1111/cas.13569.
2. Packer LM, et al. Cancer Discov. 2015 Apr; 5 (4):355-7.
3. Yamamoto M, et al. Cancer Sci. 2018 Mar 13. doi: 10.1111/cas.13569.
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Product Notes
The BLU9931 (Catalog #AAA3602173) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "BLU9931, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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