Afatinib dimaleate Biochemical

Afatinib dimaleate

Cat. Num. AAA8400512

• Purity: >=95%
• Synonyms: Afatinib dimaleate; Gilotrif; (2E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-(((3S)-tetrahydrofuran-3-yl)oxy)quinazolin- 6-yl)-4-(dimethylamino)but-2-enamide bis(hydrogen (2Z)-but-2-enedioate); (2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide dimaleate; (E)-4-Dimethylamino-But-2-Enoic Acid-(4-(3-Chloro-4-Fluoro-Phenylamino)-7-((S)-Tetra-Hydrofuran-3-Yloxy)-Quinazolin-6Yl)-Amide Dimaleate; BIBW 2992MA2; Tovok; Afatinib dimaleate biochemical

• Specificity: An inhibitor of EGFR and HER2
• Purity/Purification: >=95%
• Form/Format: White to off-white powder

• Solubilities: ~ 50mg/ml in water
• Molecular Formula: C??H??ClFN?O??
• InChi: InChI=1S/C24H25ClFN5O3.2C4H4O4/c1-31(2)8-3-4-23(32)30-21-11-17-20(12-22(21)34-16-7-9-33-13-16)27-14-28-24(17)29-15-5-6-19(26)18(25)10-15;2*5-3(6)1-2-4(7)8/h3-6; 10-12; 14; 16H; 7-9; 13H2; 1-2H3; (H; 30; 32)(H; 27; 28; 29);2*1-2H; (H; 5; 6)(H; 7; 8)/b4-3+;2*2-1-/t16-;;/m0../s1
• InChi Key: USNRYVNRPYXCSP-JUGPPOIOSA-N
• SMILES: CN(C)CC=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OC4CCOC4.C(=CC(=O)O)C(=O)O.C(=CC(=O)O)C(=O)O
• CAS Number: 850140-73-7
• MDL Number: MFCD25974239
• PubChem CID: 15606394
• Preparation and Storage: Store at -20 degree C; Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.; Shelf Life: Est.~36 months; Country of Origin: USA

Structure

Related Product Information for Afatinib dimaleate biochemical

Afatinib is an irreversible dual inhibitor of epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2) tyrosine kinase. It shows IC50 values of 0.5nM and 14nM for EGFR kinase and HER2 kinase respectively. It inhibits EGF-induced EGFR phosphorylation and cellular proliferation in cell lines such as EGFR-overexpressing and HER2-expressing cell lines A431, NIH-3T3-HER2, NCI-N87 and BT-474. It causes tumour regression in mice carrying EGFR-overexpressing and HER2-expressing A431 xenografts, EGFR-overexpressing and HER2-expressing MDA-MB-453 xenografts and NCI-N87 gastric and SKOV-3 ovarian models.

Product Categories/Family for Afatinib dimaleate biochemical

Web Categories; Enzyme Inhibitors; Protein Kinase Inhibitors; Protein Kinase Inhibitors (A-Z); Cancer Research; Oncogenic Signaling Pathway; Signaling Pathways; EGFR Signaling; EGFR Inhibitors; Biochemicals; Biochemicals (A-Z); Protein Tyrosine Kinase Inh

References

https://pubchem.ncbi.nlm.nih.gov/compound/15606394