Fc gamma RIV/CD16-2 Recombinant Protein | Fcgr4 recombinant protein

Human CellExp Fc gamma RIV/CD16-2, Mouse recombinant

Cat. Num. AAA8400050

• Gene Names: Fcgr4; Fcrl3; CD16-2; FcgRIV; Fcgr3a; FcgammaRIV; 4833442P21Rik
• Purity: >90% by SDS-PAGE
• Synonyms: Fc gamma RIV/CD16-2; Human CellExp Fc gamma RIV/CD16-2; Mouse recombinant; Fc gamma RIV; CD16-2; Fcgr4; Fcgr4 recombinant protein

• Host: HEK293 cells
• Purity/Purification: >90% by SDS-PAGE
• Form/Format: Lyophilized powder. Lyophilized from 0.22umfiltered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.
• Sequence: aaGly21-Gln203

• Gene Source: Mouse
• Endotoxin: Less than 1.0 EU per ug by the LAL method.
• Reconstitution Instruction: Reconstitute in sterile deionized water to the desired protein concentration.
• Tag Note: This protein carries a polyhistidine tag at the C-terminus.
• Preparation and Storage: Store at -20 degree C; Centrifuge the vial prior to opening.; Shelf life: ~12 months

SDS-Page

Testing Data

Related Product Information for Fcgr4 recombinant protein

FcgR4 (Low affinity immunoglobulin gamma Fc region receptor IV) is also known as CD16-2, FcgammaRIV, receptor for the Fc region of immunoglobulin gamma. Also acts as a receptor for the Fc region of immunoglobulin epsilon. Binds with intermediate affinity to both IgG2a and IgG2b. Does not display binding to IgG1 or IgG3. Plays a role in promoting bone resorption by enhancing osteoclast differentiation following binding to IgG2a. Binds with low affinity to both the a and b allotypes of IgE. Has also been shown to bind to IgE allotype a only but not to allotype b. Binding to IgE promotes macrophage-mediated phagocytosis, antigen presentation to T cells, production of proinflammatory cytokines and the late phase of cutaneous allergic reactions. Plays a role in promoting bone resorption by enhancing osteoclast differentiation following binding to IgG2a

Product Categories/Family for Fcgr4 recombinant protein

Cancer Research; Growth Factors; Cytokines & Growth Factors (A-Z); Proteins; Enzymes; Proteins & Enzymes (A-Z); Cancer Research; CDs; Cytokines; Growth Factors & Hormones; CDs; Human cell expressed recombinant proteins

NCBI and Uniprot Product Information

• NCBI GI #: 224922770
• NCBI GeneID: 246256
• NCBI Accession #: NP_653142.2
• NCBI GenBank Nucleotide #: NM_144559.2
• UniProt Accession #: A0A0B4J1G0; Q3TC44; Q8R2R4; Q8R477
• Molecular Weight: 28,398 Da
• NCBI Official Full Name: low affinity immunoglobulin gamma Fc region receptor IV
• NCBI Official Synonym Full Names: Fc receptor, IgG, low affinity IV
• NCBI Official Symbol: Fcgr4
• NCBI Official Synonym Symbols: Fcrl3; CD16-2; FcgRIV; Fcgr3a; FcgammaRIV; 4833442P21Rik
• NCBI Protein Information: low affinity immunoglobulin gamma Fc region receptor IV
• UniProt Protein Name: Low affinity immunoglobulin gamma Fc region receptor IV
• UniProt Gene Name: Fcgr4

Uniprot Description

Receptor for the Fc region of immunoglobulin gamma (PubMed:16039578). Also acts as a receptor for the Fc region of immunoglobulin epsilon (PubMed:17558411, PubMed:18949059). Binds with intermediate affinity to both IgG2a and IgG2b (PubMed:16039578, PubMed:17558411, PubMed:19795417). Can bind to IgG2a and IgG2b monomers (PubMed:18949059). Does not display binding to IgG1 or IgG3 (PubMed:16039578). Mediates neutrophil activation by IgG complexes redundantly with Fcgr3 (PubMed:18097064). Plays a role in promoting bone resorption by enhancing osteoclast differentiation following binding to IgG2a (PubMed:25824719). Binds with low affinity to both the a and b allotypes of IgE (PubMed:18949059). Has also been shown to bind to IgE allotype a only but not to allotype b (PubMed:17558411). Binds aggregated IgE but not the monomeric form and bound monomeric IgG is readily displaced by IgE complexes (PubMed:18949059). Binding to IgE promotes macrophage-mediated phagocytosis, antigen presentation to T cells, production of proinflammatory cytokines and the late phase of cutaneous allergic reactions (PubMed:17558411, PubMed:18949059).