Complement C5a Recombinant Protein | C5 recombinant protein

Human CellExp Complement C5a, Mouse recombinant

Cat. Num. AAA8400051

• Gene Names: Hc; C5; He; C5a
• Purity: >95% by SDS-PAGE
• Synonyms: Complement C5a; Human CellExp Complement C5a; Mouse recombinant; C5a; Complement Component 5a; Hemolytic complement; C5 recombinant protein

• Host: E Coli
• Purity/Purification: >95% by SDS-PAGE
• Form/Format: Lyophilized powder. Lyophilized from 0.22um filtered solution in PBS, pH7.4. Normally trehaloseis added as protectant before lyophilization.
• Sequence: aaAsn679-Arg755

• Gene Source: Mouse
• Endotoxin: Less than 1.0 EU per ug by the LAL method.
• Reconstitution Instruction: Reconstitute in sterile deionized water to the desired protein concentration.
• Tag Note: This protein carries a polyhistidine tag at the N-terminus.
• Preparation and Storage: Store at -20 degree C; Centrifuge the vial prior to opening.; Shelf life: ~12 months

SDS-Page

Testing Data

Related Product Information for C5 recombinant protein

Complement Component C5a (C5a) is also known as C5,and is a protein fragment released from complement component C5, is a potent chemotactic factor for human peripheral blood neutrophils and monocytes, and is believed to play an important role in a number of inflammatory conditions. There are several functions in the below: C5a is an anaphylatoxin, causing the release of histamine from mast cells; C5a is effective leukocyte chemoattractants, causing the accumulation of white blood cells, especially neutrophil granulocytes, at sites of complement activation; C5a activates white blood cells by increasing avidity for white blood cell integrins and upregulating the Lipoxygenase pathway for arachidonic acid metabolism; C5a is a powerful inflammatory mediator, and seems to be a key factor in the development of pathology of many inflammatory diseases involving the complement system; C5a modulates balance between activating versus inhibitory IgG Fc receptors on leukocytes, thereby enhancing autoimmune response.

Product Categories/Family for C5 recombinant protein

Proteins; Enzymes; Cytokines; Growth Factors & Hormones; Cytokines & Growth Factors (A-Z); CDs; Human cell expressed recombinant proteins

NCBI and Uniprot Product Information

• NCBI GI #: 6754164
• NCBI GeneID: 15139
• NCBI Accession #: NP_034536.1
• NCBI GenBank Nucleotide #: NM_010406.2
• UniProt Accession #: P06684; A2AS36
• NCBI Official Full Name: complement C5 preproprotein
• NCBI Official Synonym Full Names: hemolytic complement
• NCBI Official Symbol: Hc
• NCBI Official Synonym Symbols: C5; He; C5a
• NCBI Protein Information: complement C5
• UniProt Protein Name: Complement C5
• Protein Family: Complement C5
• UniProt Gene Name: C5
• UniProt Synonym Gene Names: Hc
• UniProt Entry Name: CO5_MOUSE

Uniprot Description

C5: Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. Defects in C5 are the cause of complement component 5 deficiency (C5D). A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. An association study of C5 haplotypes and genotypes in individuals with chronic hepatitis C virus infection shows that individuals homozygous for the C5_1 haplotype have a significantly higher stage of liver fibrosis than individuals carrying at least 1 other allele (PubMed:15995705).

Protein type: Secreted, signal peptide; Secreted

Cellular Component: membrane attack complex; extracellular space; extracellular region

Molecular Function: endopeptidase inhibitor activity

Biological Process: positive regulation of angiogenesis; in utero embryonic development; immune system process; cytolysis; complement activation, alternative pathway; innate immune response; inflammatory response; complement activation, classical pathway