IL-2 R alpha/CD25 Active Protein | Il2ra active protein

Human CellExp IL-2 R alpha/CD25, Mouse Recombinant

Cat. Num. AAA8400087

• Gene Names: Il2ra; CD25; Il2r; Ly-43
• Purity: >90% by SDS-PAGE
• Synonyms: IL-2 R alpha/CD25; Human CellExp IL-2 R alpha/CD25; Mouse Recombinant; IL2RA; CD25; p55; IL2-RA; IL-2-RA; Il2ra active protein

• Host: HEK293 cells
• Purity/Purification: >90% by SDS-PAGE
• Form/Format: Lyophilized powder. Lyophilized from 0.22um filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.
• Sequence: Glu22-Lys236

• Gene Source: Mouse
• Endotoxin: Less than 1.0 EU per ug by the LAL method.
• Biological Activity: Immobilized Biotinylated Human IL-2, Fc Tag, A at 5 ug/mL (100 uL/well)on streptavidin precoated (0.5 ug/well)plate, can bind Mouse IL-2 R alpha with a linear range of 5-40 ng/mL. Immobilized Mouse IL-2 R alpha at 5 ug/mL (100 uL/well) can bind Biotinylated Human IL-2 with a linear range of 0.6-10 ng/mL
• Reconstitution Instruction: Reconstitute in sterile deionized water to the desired protein concentration.
• Tag Note: This protein carries a polyhistidine tag at the C-terminus.
• Preparation and Storage: Store at -20 degree C; Centrifuge the vial prior to opening.; Shelf life: ~12 months

SDS-Page

Testing Data

Testing Data

Related Product Information for Il2ra active protein

Interleukin-2 receptor subunit alpha (IL2RA) is also known as IL-2R subunit alpha, IL-2-RA, IL2-RA, TAC antigen, p55, CD antigen CD25, is a type I transmembrane glycoprotein. IL2RA is expressed on activated T cells and regulatory T cells, and is capable of binding IL2 with low affinity by itself. However, a ligand-induced high affinity heterotrimeric receptor complex is produced when IL2RA is associated non-covelently with the IL2 receptor beta and gamma chain, and subsequently initiates the intacellular signal pathways such as MAPK or JAK/STAT. On dendritic cells (DC), CD25 has been previously regarded as an activation marker, while both murine and human DC can express CD25, they do not express the beta-chain of the IL-2 receptor, which is indispensable for the execution of IL-2 signaling.

Product Categories/Family for Il2ra active protein

Proteins; Enzymes; Proteins & Enzymes (A-Z); Cytokines; Growth Factors & Hormones; Cytokines & Growth Factors (A-Z); CDs; Human cell expressed recombinant proteins

NCBI and Uniprot Product Information

• NCBI GI #: 124318
• NCBI GeneID: 16184
• UniProt Accession #: P01590; Q61731
• Molecular Weight: 30,723 Da
• NCBI Official Full Name: Interleukin-2 receptor subunit alpha
• NCBI Official Synonym Full Names: interleukin 2 receptor, alpha chain
• NCBI Official Symbol: Il2ra
• NCBI Official Synonym Symbols: CD25; Il2r; Ly-43
• NCBI Protein Information: interleukin-2 receptor subunit alpha; IL2-RA; IL-2-RA; p55 chain; IL-2R alpha chain; IL-2R subunit alpha; IL-2 receptor subunit alpha
• UniProt Protein Name: Interleukin-2 receptor subunit alpha
• Protein Family: Interleukin-2 receptor
• UniProt Gene Name: Il2ra
• UniProt Synonym Gene Names: Il2r; IL-2 receptor subunit alpha; IL-2-RA; IL-2R subunit alpha; IL2-RA
• UniProt Entry Name: IL2RA_MOUSE

Uniprot Description

IL2RA: Receptor for interleukin-2. Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit.

Protein type: Membrane protein, integral

Cellular Component: cell surface; membrane; integral to membrane; external side of plasma membrane

Molecular Function: protein binding; interleukin-2 receptor activity; drug binding; interleukin-2 binding

Biological Process: Notch signaling pathway; regulation of T cell homeostatic proliferation; negative regulation of immune response; negative regulation of defense response to virus; positive regulation of activated T cell proliferation; negative regulation of lymphocyte proliferation; inflammatory response to antigenic stimulus; negative regulation of T cell proliferation; positive regulation of T cell differentiation; negative regulation of inflammatory response; T cell homeostasis; positive regulation of T cell proliferation; immune response; activated T cell apoptosis