CSRP1 recombinant protein

CSRP1 Protein, Mouse, Recombinant (His Tag)

Cat. Num. AAA8122803

• Gene Names: Csrp1; CRP1; Csrp; AA408841; AA959891; AW545626
• Purity: >95% as determined by SDS-PAGE
• Synonyms: CSRP1; CSRP1 Protein; Mouse; Recombinant (His Tag); Mouse CSRP1/CSRP/CRP1 Protein (His Tag); AA408841 Protein; AA959891 Protein; AW545626 Protein; CRP1 Protein; Csrp Protein; cysteine and glycine-rich protein 1; CSRP1 recombinant protein

• Host: E Coli
• Purity/Purification: >95% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Met1-Glu193

• Species: Mouse
• Predicted N Terminal: Met
• Tag: C-His
• Protein Construction: A DNA sequence encoding the mouse CSRP1 (P97315)(Met 1-Glu 193) was expressed, with a polyhistide tag at the C-terminus.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

SDS-Page

Related Product Information for CSRP1 recombinant protein

Background: Cysteine and glycine-rich protein 1, also known as Cysteine-rich protein 1, CSRP1 and CSRP, is a member of the CSRP family which may be involved in regulatory processes important for development and cellular differentiation. CSRP1 contains twoLIM zinc-binding domains. The LIM/double zinc-finger motif found in CSRP1 is found in a group of proteins with critical functions in gene regulation, cell growth, and somatic differentiation. Zebrafish CSRP1 is expressed in the mesendoderm and its derivatives. CSRP1 interacts with Dishevelled 2 (Dvl2) and Diversin (Div), which control cell morphology and other dynamic cell behaviors via the noncanonical Wnt and JNK pathways. When CSRP1 message is knocked down, abnormal convergent extension cell movement is induced, resulting in severe deformities in midline structures. In addition, cardiac bifida is induced as a consequence of defects in cardiac mesoderm cell migration. CSRP1 acts as a key molecule of the noncanonical Wnt pathway, which orchestrates cell behaviors during dynamic morphogenetic movements of tissues and organs.

References

Wimmer,U. et al., 2005, Nucleic acids Res. 33 (18):5715-27. Miyasaka, KY.et al., 2007, Proc Natl Acad Sci USA. 104 (27): 11274-9. Zhou,C.Z. et al., 2008,Chin Med J. 121 (24): 2479-86. Lilly,B. et al., 2010, Arterioscler Thromb Vasc Biol. 30 (4):694-701.

NCBI and Uniprot Product Information

• NCBI GI #: 6681069
• NCBI GeneID: 13007
• NCBI Accession #: NP_031817.1
• NCBI GenBank Nucleotide #: NM_007791.5
• UniProt Accession #: P97315
• Molecular Weight: 20,583 Da
• NCBI Official Full Name: cysteine and glycine-rich protein 1
• NCBI Official Synonym Full Names: cysteine and glycine-rich protein 1
• NCBI Official Symbol: Csrp1
• NCBI Official Synonym Symbols: CRP1; Csrp; AA408841; AA959891; AW545626
• NCBI Protein Information: cysteine and glycine-rich protein 1; CRP; cysteine rich protein 1; cysteine-rich protein 1
• UniProt Protein Name: Cysteine and glycine-rich protein 1
• Protein Family: Cysteine and glycine-rich protein
• UniProt Gene Name: Csrp1
• UniProt Synonym Gene Names: Crp1; Csrp; CRP; CRP1
• UniProt Entry Name: CSRP1_MOUSE