DEDD2 blocking peptide

DEDD2 Blocking Peptide (Center)

• Gene Names: DEDD2; FLAME-3
• Synonyms: DEDD2; DEDD2 Blocking Peptide (Center); DNA-binding death effector domain-containing protein 2; DED-containing protein FLAME-3; FADD-like anti-apoptotic molecule 3; FLAME3; DEDD2 blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 182-193 of HUMAN DEDD2
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 326

• Cellular Location: Nucleus, nucleolus. Note: Nuclear, accumulated in subnuclear structures resembling nucleoli
• Tissue Location: Expressed in most tissues. High levels were found in liver, kidney, heart, ovary, spleen, testes, skeletal muscle and peripheral blood leukocytes. Expression was absent or low in colon and small intestine. Expression is relatively high in the tumor cell lines chronic myologenous leukemia K-562 and the colorectal adenocarcinoma SW480. Expression is moderate in the cervical carcinoma HeLa, the Burkitt's lymphoma Raji, the lung carcinoma A-549, and the melanoma G-361. In contrast, two leukemia cell lines, HL-60 (promyelocytic leukemia) and MOLT-4 (lymphoblastic leukemia), show relatively low levels
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for DEDD2 blocking peptide

May play a critical role in death receptor-induced apoptosis and may target CASP8 and CASP10 to the nucleus. May regulate degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3.

NCBI and Uniprot Product Information

• NCBI GI #: 47116024
• NCBI GeneID: 162989
• UniProt Accession #: Q8WXF8; Q8NBR2; Q8NES1; Q8TAA8; Q96D35
• Molecular Weight: 35,577 Da
• NCBI Official Full Name: DNA-binding death effector domain-containing protein 2
• NCBI Official Synonym Full Names: death effector domain containing 2
• NCBI Official Symbol: DEDD2
• NCBI Official Synonym Symbols: FLAME-3
• NCBI Protein Information: DNA-binding death effector domain-containing protein 2
• UniProt Protein Name: DNA-binding death effector domain-containing protein 2
• Protein Family: DNA-binding death effector domain-containing protein
• UniProt Gene Name: DEDD2
• UniProt Synonym Gene Names: FLAME3
• UniProt Entry Name: DEDD2_HUMAN

NCBI Description

This gene encodes a nuclear-localized protein containing a death effector domain (DED). The encoded protein may regulate the trafficking of caspases and other proteins into the nucleus during death receptor-induced apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

Uniprot Description

DEDD2: May play a critical role in death receptor-induced apoptosis and may target CASP8 and CASP10 to the nucleus. May regulate degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Nucleolus

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: nucleolus; nucleoplasm

Molecular Function: DNA binding; protein binding

Biological Process: apoptotic nuclear changes; induction of apoptosis via death domain receptors