Rabbit NUP107 Polyclonal Antibody | anti-NUP107 antibody

NUP107 Antibody

Cat. Num. AAA9414795

• Gene Names: NUP107; NUP84
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunocytochemistry
• Purity: Affinity chromatography purified via peptide column
• Synonyms: NUP107; Polyclonal Antibody; NUP107 Antibody; Nucleoporin 107; nuclear pore complex protein 107; anti-NUP107 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Purity/Purification: Affinity chromatography purified via peptide column
• Form/Format: Supplied in PBS containing 0.02% sodium azide.
• Sequence Length: 925

• Applicable Applications for anti-NUP107 antibody: ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC)
• Immunogen Type: Peptide
• Immunogen Description: Raised against a 20 amino acid peptide from near the center of human NUP107.
• Target Name: NUP107
• Preparation and Storage: Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of NUP107 in A549 cell lysate with NUP107 antibody at (A) 1 and (B) 2 ug/mL.)

Immunocytochemistry (ICC)

(Immunocytochemistry of NUP107 in A549 cells with NUP107 antibody at 10 ug/mL.)

Related Product Information for anti-NUP107 antibody

The nuclear pore complex (NPC) is a protein assembly localized at the nuclear rim and mediates macromolecular transport between the nucleus and the cytoplasm. The mammalian nucleoporin (NUP)-107 is part of the hetero-oligomeric complex that also contains NUP160, NUP133, NUP96, and mammalian homolog of yeast sec13p. While the majority of the NUP107-160 nuclear pore sub-complex localizes to the nuclear pore, a small fraction is observed at kinetochores and pro-metaphase spindle poles in mitotic cells in association with proteins such as Mad1, Mad2, Bub3 and Cdc20. Immunodepletion of the NUP107-160 complex resulted in defective spindle assembly indicating that it has multiple functions. NUP107 has recently been identified as an HIV dependency factor (HDF), suggesting that NUP107 may be an important drug target in HIV treatment. Multiple isoforms of NUP107 are known to exist.

Product Categories/Family for anti-NUP107 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 9966881
• NCBI GeneID: 57122
• NCBI Accession #: NP_065134.1
• NCBI GenBank Nucleotide #: NM_020401.2
• UniProt Accession #: P57740; Q6PJE1; B4DZ67
• Molecular Weight: 79,971 Da
• NCBI Official Full Name: nuclear pore complex protein Nup107
• NCBI Official Synonym Full Names: nucleoporin 107kDa
• NCBI Official Symbol: NUP107
• NCBI Official Synonym Symbols: NUP84
• NCBI Protein Information: nuclear pore complex protein Nup107
• UniProt Protein Name: Nuclear pore complex protein Nup107
• Protein Family: Nucleoporin
• UniProt Gene Name: NUP107
• UniProt Entry Name: NU107_HUMAN

NCBI Description

This gene encodes a member of the nucleoporin family. The protein is localized to the nuclear rim and is an essential component of the nuclear pore complex (NPC). All molecules entering or leaving the nucleus either diffuse through or are actively transported by the NPC. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]

Uniprot Description

NUP107: Essential component of nuclear pore complex. Required for the assembly of peripheral proteins into the nuclear pore complex. Belongs to the nucleoporin Nup84/Nup107 family.

Protein type: Nucleoporin

Chromosomal Location of Human Ortholog: 12q15

Cellular Component: kinetochore; nucleoplasm; centrosome; nuclear membrane; membrane; nuclear pore; nuclear envelope; cytosol

Molecular Function: protein binding; structural constituent of nuclear pore; nucleocytoplasmic transporter activity

Biological Process: nuclear pore complex assembly; viral reproduction; cytokine and chemokine mediated signaling pathway; mitotic nuclear envelope disassembly; pathogenesis; viral infectious cycle; glucose transport; protein transport; mRNA export from nucleus; hexose transport; carbohydrate metabolic process; gene expression; viral transcription; mitotic cell cycle; transmembrane transport