Rabbit anti-Human DEDD2 Polyclonal Antibody | anti-DEDD2 antibody

DEDD2 Antibody (Center)

Cat. Num. AAA9216997

• Gene Names: DEDD2; FLAME-3
• Reactivity: Human
• Applications: Western Blot
• Synonyms: DEDD2; Polyclonal Antibody; DEDD2 Antibody (Center); Purified Rabbit Polyclonal Antibody (Pab); DNA-binding death effector domain-containing protein 2; DED-containing protein FLAME-3; FADD-like anti-apoptotic molecule 3; FLAME3; anti-DEDD2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Sequence Length: 326

• Applicable Applications for anti-DEDD2 antibody: Western Blot (WB)
• Application Notes: WB~~1:2000
• Antigen Type: Synthesized Peptide
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Western Blot (WB)

(Anti-DEDD2 Antibody (Center) at 1:2000 dilution + SW480 whole cell lysateLysates/proteins at 20 ug per lane. SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 36 kDaBlocking/Dilution buffer: 5% NFDM/TBST.)

Related Product Information for anti-DEDD2 antibody

May play a critical role in death receptor-induced apoptosis and may target CASP8 and CASP10 to the nucleus. May regulate degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3.

Product Categories/Family for anti-DEDD2 antibody

Cell Biology

References

Roth W.,et al.J. Biol. Chem. 277:7501-7508(2002). Zhan Y.,et al.Cell Death Differ. 9:439-447(2002). Lee J.C.,et al.J. Cell Biol. 158:1051-1066(2002). Otsuki T.,et al.DNA Res. 12:117-126(2005). Alcivar A.,et al.Oncogene 22:291-297(2003).

NCBI and Uniprot Product Information

• NCBI GI #: 396941648
• NCBI GeneID: 162989
• NCBI Accession #: NP_001257543.1
• NCBI GenBank Nucleotide #: NM_001270614.1
• UniProt Accession #: Q8WXF8; Q8NBR2; Q8NES1; Q8TAA8; Q96D35
• Molecular Weight: 35,577 Da
• NCBI Official Full Name: DNA-binding death effector domain-containing protein 2 isoform 1
• NCBI Official Synonym Full Names: death effector domain containing 2
• NCBI Official Symbol: DEDD2
• NCBI Official Synonym Symbols: FLAME-3
• NCBI Protein Information: DNA-binding death effector domain-containing protein 2
• UniProt Protein Name: DNA-binding death effector domain-containing protein 2
• Protein Family: DNA-binding death effector domain-containing protein
• UniProt Gene Name: DEDD2
• UniProt Synonym Gene Names: FLAME3
• UniProt Entry Name: DEDD2_HUMAN

NCBI Description

This gene encodes a nuclear-localized protein containing a death effector domain (DED). The encoded protein may regulate the trafficking of caspases and other proteins into the nucleus during death receptor-induced apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

Uniprot Description

DEDD2: May play a critical role in death receptor-induced apoptosis and may target CASP8 and CASP10 to the nucleus. May regulate degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Nucleolus

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: nucleolus; nucleoplasm

Molecular Function: DNA binding; protein binding; receptor signaling complex scaffold activity

Biological Process: apoptotic nuclear changes; cellular homeostasis; induction of apoptosis via death domain receptors; negative regulation of transcription, DNA-dependent; RNA processing; rRNA catabolic process; transcription, DNA-dependent