Dilution Information
Rabbit anti-Human INI-1 Monoclonal Antibody | anti-INI-1 antibody
INI-1 (RBT-INI1)
Reactivity
Human
Synonyms
INI-1; Monoclonal Antibody; INI-1 (RBT-INI1); ini-1; anti-ini-1; ini1; anti-ini1;; smarcb1; anti-smarcb1; baf47; anti-baf-47; hsnf5; anti-hsnf5; anti-INI-1 antibody
Host
Rabbit
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG
Clone Number
RBT-INI1
Form/Format
Paraffin, Frozen
INI-1 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
INI-1 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
Immunogen
Recombinant protein corresponding to the human SMARCB1 protein.
Control
Testis, Brain, Breast, Colon
Localization
Nuclear
Preparation and Storage
Store at 2-8 degree C (Control Slides: Store at 20-25 degree C)
Dilution Information
Dilution Information
Immunohistochemistry (IHC)
(INI-1 Antibody Immunohistochemistry on an FFPE Ewing's Sarcoma Tissue)
Immunohistochemistry (IHC)
(INI-1 Antibody Immunohistochemistry on an FFPE Ewing's Sarcoma Tissue)
Related Product Information for anti-INI-1 antibody
The INI-1 gene, which encodes a functionally uncharacterized protein component of the hSWI/SNF chromatin remodeling complex, is involved in chromatin remodeling and transcriptional regulation and also known as hSNF5, SMARCB1 and BAF47.
INI-1 is often mutated or deleted in malignant rhabdoid tumor (MRT). Two isoforms of INI-1, that differ by the variable inclusion of amino acids, potentially are produced by differential RNA splicing. The morphology of MRTs can present challenges in differential identification. The overall survival of MRTs relative to its potential mimics such as medulloblastoma and supratentorial primitive neuroectodermal tumors (sPNETs) is quite low, and thus differentiation from these other tumors is desirable. Lack of nuclear labeling by INI-1 is characteristic of MRT. The majority of medulloblastomas and sPNETs are labeled by INI-1 antibody. MRTs also originate from the kidney and soft tissues. Germline INI-1 mutations are associated with sporadic schwannomatosis and rhabdoid tumors. INI-1 antibody has been used to distinguish atypical teratoid/rhabdoid tumor (loss of INI1) from choroid plexus carcinoma (positive for INI-1) and to differentiate epithelioid sarcoma (loss of INI1) from epithelioid hemangioendothelioma (positive for INI-1).
INI-1 is often mutated or deleted in malignant rhabdoid tumor (MRT). Two isoforms of INI-1, that differ by the variable inclusion of amino acids, potentially are produced by differential RNA splicing. The morphology of MRTs can present challenges in differential identification. The overall survival of MRTs relative to its potential mimics such as medulloblastoma and supratentorial primitive neuroectodermal tumors (sPNETs) is quite low, and thus differentiation from these other tumors is desirable. Lack of nuclear labeling by INI-1 is characteristic of MRT. The majority of medulloblastomas and sPNETs are labeled by INI-1 antibody. MRTs also originate from the kidney and soft tissues. Germline INI-1 mutations are associated with sporadic schwannomatosis and rhabdoid tumors. INI-1 antibody has been used to distinguish atypical teratoid/rhabdoid tumor (loss of INI1) from choroid plexus carcinoma (positive for INI-1) and to differentiate epithelioid sarcoma (loss of INI1) from epithelioid hemangioendothelioma (positive for INI-1).
Similar Products
Product Notes
The INI-1 (Catalog #AAA370544) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The INI-1 (RBT-INI1) reacts with Human and may cross-react with other species as described in the data sheet. It is sometimes possible for the material contained within the vial of "INI-1, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
