Structure
Vps34 inhibitor PIK-III, Inhibitor
Vps34 inhibitor PIK-III
Purity
>98% (HPLC)
Synonyms
Vps34 inhibitor PIK-III; PIK-III; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: >=31mg/mL
Target
PI3K
Receptor
PI3Kalpha; PI3Kbeta; PI3Kgamma; PI3Kdelta; Vps34
Chemical Name
[4, 5'-Bipyrimidine]-2, 2'-diamine, 4'-(cyclopropylmethyl)-N2-4-pyridinyl
SMILES
NC1=NC=C(C2=NC(NC3=CC=NC=C3)=NC=C2)C(CC4CC4)=N1
Molecular Formula
C17H17N7
CAS Number
1383716-40-2
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Vps34 inhibitor PIK-III, inhibitor
Vps34 inhibitor PIK-III (PIK-III) is a potent, selective inhibitor of Vps34 with IC50 of 18nM, shows >100-fold selectivity over other class I PI3Ks, PI4Kbeta and mTOR; inhibits the localization of GFP-FYVE in mammalian cells with IC50 of 55nM, which is >10,000 times more potent than the non-selective VPS34 inhibitor 3-MA; robustly inhibits autophagy and LC3 lipidation, leads to the stabilization of autophagy substrates in mammalian cells.
Product Categories/Family for Vps34 inhibitor PIK-III, inhibitor
References
1. Dowdle WE, et al. Nat Cell Biol. 2014 Nov; 16 (11):1069-79.
2. Honda A, et al. ACS Med Chem Lett. 2015 Nov 13; 7 (1):72-6.
2. Honda A, et al. ACS Med Chem Lett. 2015 Nov 13; 7 (1):72-6.
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Product Notes
The Vps34 inhibitor PIK-III (Catalog #AAA3601589) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Vps34 inhibitor PIK-III, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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