Structure
PIK-93, Inhibitor
PIK-93
Purity
>98% (HPLC)
Synonyms
PIK-93; PIK 93; PIK93; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
10mM in DMSO
Target
PI4K
Receptor
ATM; C2beta; DNA-PK; hsVps34; mTORC1; p110alpha; p110beta; p110gamma; p110delta; PI3KIIIbeta
Chemical Name
Acetamide, N-[5-[4-chloro-3-[[(2-hydroxyethyl)amino]sulfonyl]phenyl]-4-methyl-2-thiazolyl]
SMILES
CC(NC1=NC(C)=C(C2=CC=C(Cl)C(S(=O)(NCCO)=O)=C2)S1)=O
Molecular Formula
C14H16ClN3O4S2
CAS Number
593960-11-3
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for PIK-93, inhibitor
PIK-93 is a potent, synthetic PI4K inhibitor with IC50 of 19nM (PI4KIIIbeta), also inhibits PI3Kgamma and PI3Kalpha with IC50 of 16nM and 39nM, respectively; also inhibits other PI3Ks, including PI3Kalpha, beta, and delta, with IC50 values of 39nM, 0.59uM, and 0.12uM, shows no inhibitory effect against a panel of other kinases; significantly inhibits the conversion of [3H]serine-labeled endogenous ceramide to sphingomyelin, reduces carbachol-induced translocation of TRPC6 to the plasma membrane and net Ca2+ entry in T6.11 cells at 300nM; also demonstrates anti-enterovirus effects by inhibition of both poliovirus and HCV replication with EC50 of 0.14uM and 1.9uM, respectively.
Product Categories/Family for PIK-93, inhibitor
References
1. Knight ZA, et al. Cell. 2006 May 19; 125 (4):733-47.
2. Monet M, et al. J Biol Chem. 2012 May 18; 287 (21):17672-81.
3. Toth B, et al. J Biol Chem. 2006 Nov 24; 281 (47):36369-77.
4. Arita M, et al. J Virol. 2011 Mar; 85 (5):2364-72.
2. Monet M, et al. J Biol Chem. 2012 May 18; 287 (21):17672-81.
3. Toth B, et al. J Biol Chem. 2006 Nov 24; 281 (47):36369-77.
4. Arita M, et al. J Virol. 2011 Mar; 85 (5):2364-72.
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Product Notes
The PIK-93 (Catalog #AAA3605200) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "PIK-93, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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