Structure
Autophinib, Inhibitor
Autophinib
Purity
>98% (HPLC)
Synonyms
Autophinib; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: 64mg/mL (184.6mM)
Ethanol: <1mg/mL
Water: <1mg/mL (<1mg/mL refers to the product slightly soluble or insoluble)
Ethanol: <1mg/mL
Water: <1mg/mL (<1mg/mL refers to the product slightly soluble or insoluble)
Target
PI3K
Receptor
rapamycin-inducedautophagy; starvation-inducedautophagy; VPS34
Chemical Name
6-Chloro-N-(5-methyl-1H-pyrazol-3-yl)-2-(4-nitrophenoxy)pyrimidin-4-amine
SMILES
O=[N+](C1=CC=C(OC2=NC(Cl)=CC(NC3=NNC(C)=C3)=N2)C=C1)[O-]
Molecular Formula
C14H11ClN6O3
CAS Number
1644443-47-9
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Autophinib, inhibitor
Autophinib is a novel, potent autophagy inhibitor that inhibits autophagy induced by starvation (IC50=90nM) or rapamycin (IC50=40nM) by targeting the lipid kinase VPS34 (IC50=19nM); inhibits LC3 lipidation to form LC3-II, also inhibits p62 degradation dose-dependently in starved MCF7-LC3 cells; an ATP-competitive inhibitor of VPS34 but not other lipid kinases, mTOR and TBK1.
Product Categories/Family for Autophinib, inhibitor
References
1. Robke L, et al. Angew Chem Int Ed Engl. 2017 Jul 3; 56 (28):8153-8157.
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Product Notes
The Autophinib (Catalog #AAA3602507) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Autophinib, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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