Osteoprotegerin/TNFRSF11B Recombinant Protein | TNFRSF11B recombinant protein

Recombinant Mouse Osteoprotegerin/TNFRSF11B Protein

Cat. Num. AAA9141889

• Gene Names: Tnfrsf11b; Opg; TR1; OCIF
• Purity: >87% by SDS-PAGE.
• Synonyms: Osteoprotegerin/TNFRSF11B; Recombinant Mouse Osteoprotegerin/TNFRSF11B Protein; TNFRSF11B; OCIF; OPG; Osteoprotegerin; TR1; TNFRSF11B recombinant protein

• Host: HEK293
• Purity/Purification: >87% by SDS-PAGE.
• Form/Format: Lyophilized from a 0.22 um filtered solution of PBS, pH 7.4.
• Sequence: MNKWLCCALLVLLDIIEWTTQETLPPKYLHYDPETGHQLLCDKCAPGTYLKQHCTVRRKTLCVPCPDHSYTDSWHTSDECVYCSPVCKELQSVKQECNRTHNRVCECEEGRYLEIEFCLKHRSCPPGSGVVQAGTPERNTVCKKCPDGFFSGETSSKAPCIKHTNCSTFGLLLIQKGNATHDNVCSGNREATQKCGIDVTLCEEAFFRFAVPTKIIPNWLSVLVDSLPGTKVNAESVERIKRRHSSQEQTFQLLKLWKHQNRDQEMVKKIIQDIDLCESSVQRHLGHSNLTTEQLLALMESLPGKKISPEEIERTRKTCKSSEQLLKLLSLWRIKNGDQDTLKGLMYALKHLKTSHFPKTVTHSLRKTMRFLHSFTMYRLYQKLFLEMIGNQVQSVKISCL
• Sequence Length: 401

• Species: Mouse
• Endotoxin: < 0.1 EU/ug of the protein by LAL method.
• Reconstitution: Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water.
• Tag: Fc, 6xHis tag at the C-terminus
• Preparation and Storage: Store the lyophilized protein at -20 degree C to -80 degree C for long term.; After reconstitution, the protein solution is stable at -20 degree C for 3 months, at 2-8 degree C for up to 1 week.

SDS-Page

(Recombinant Mouse Osteoprotegerin/TNFRSF11B Protein was determined by SDS-PAGE with Coomassie Blue, showing a band at 100kDa.)

Related Product Information for TNFRSF11B recombinant protein

Recombinant Mouse Osteoprotegerin/TNFRSF11B Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Met1-Leu401) of mouse Osteoprotegerin/TNFRSF11B (Accession #NP_032790.3) fused with an Fc, 6xHis tag at the C-terminus.

Product Categories/Family for TNFRSF11B recombinant protein

Cytokines & Cytokine Receptors

NCBI and Uniprot Product Information

• NCBI GI #: 113930716
• NCBI GeneID: 18383
• NCBI Accession #: NP_032790.3
• NCBI GenBank Nucleotide #: NP_032790.3
• UniProt Accession #: O08712
• NCBI Official Full Name: tumor necrosis factor receptor superfamily member 11B
• NCBI Official Synonym Full Names: tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)
• NCBI Official Symbol: Tnfrsf11b
• NCBI Official Synonym Symbols: Opg; TR1; OCIF
• NCBI Protein Information: tumor necrosis factor receptor superfamily member 11B
• UniProt Protein Name: Tumor necrosis factor receptor superfamily member 11B
• Protein Family: Tumor necrosis factor receptor superfamily
• UniProt Gene Name: Tnfrsf11b
• UniProt Synonym Gene Names: Ocif; Opg

Uniprot Description

TNFRSF11B: Acts as decoy receptor for RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local RANKL/OPG ratio. May also play a role in preventing arterial calcification. May act as decoy receptor for TRAIL and protect against apoptosis. TRAIL binding blocks the inhibition of osteoclastogenesis. Defects in TNFRSF11B are the cause of juvenile Paget disease (JPD); also known as hyperostosis corticalis deformans juvenilis or hereditary hyperphosphatasia or chronic congenital idiopathic hyperphosphatasia. JPD is a rare autosomal recessive osteopathy that presents in infancy or early childhood. The disorder is characterized by rapidly remodeling woven bone, osteopenia, debilitating fractures, and deformities due to a markedly accelerated rate of bone remodeling throughout the skeleton. Approximately 40 cases of JPD have been reported worldwide. Unless it is treated with drugs that block osteoclast- mediated skeletal resorption, the disease can be fatal.

Protein type: Inhibitor; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 15|15 D1

Cellular Component: extracellular space; integral to plasma membrane; proteinaceous extracellular matrix

Molecular Function: tumor necrosis factor receptor activity

Biological Process: extracellular matrix organization and biogenesis; immune response; inflammatory response; negative regulation of bone resorption; negative regulation of odontogenesis of dentine-containing teeth; positive regulation of MAPKKK cascade; regulation of apoptosis; regulation of cell proliferation; response to lipopolysaccharide