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67 results for "DNA PK inhibitor" - showing 1-50
Testing Data
(Published customer image: Mouse anti V5 tag antibody, clone SV5-Pk1 used for detection of V5 tagged REDD1 protein by western blotting.Image caption:REDD1 is not degraded by Cul4a or phosphorylated by GSK3beta at Thr 23 and Thr25. (A) HEK293 cells were transfected with empty vector or tetracycline inducible dnCul4a-V5 pcDNA4/TO (1 ug) and Cul4A-V5 pcDNA3 (0.03 ug) followed by tetracycline (1 ug/ml) induction for 24 hours and cell lysis. (B) HEK293 cells were transfected with 0.5 ug Cul4a-V5 pcDNA3 for 15 hours followed by transfection of 20 nM control or Cul4a siRNAs to determine siRNAs efficiency. (C) HEK293 cells were transfected with 20 nM control or Cul4a siRNAs for 3 days followed by cell lysis. (D) REDD1-V5 pcDNA3 wild type, T23A T25A or T23D T25D plasmids (0.4 ug) were transfected in HEK293 cells for 3 days and treated with 20 uM MG-132 for 6 hours followed by cell lysis. (E) HEK293 cells were treated with 30 mM LiCl or GSK3 inhibitor IX (5 uM or 10 uM) for 20 hours followed by cell lysis. (F) HEK293 cells were co-transfected with 0.2 ug REDD1-V5 pcDNA3 and 0.3 ug GSK3beta pcDNA3 or empty pcDNA3 for 3 days followed by MG-132 (20 uM) treatment for 6 hours followed by cell lysis. (G) HEK293 cells were transfected with 3 ug DYKDDDDK-REDD1 or DYKDDDDK-FRAT1 for 3 days followed by cell lysis and DYKDDDDK immunoprecipitation. In vitro phosphorylation of REDD1 and FRAT1 was carried out as described in Materials and Methods..From: Tan CY, Hagen T (2013) mTORC1 Dependent Regulation of REDD1 Protein Stability. PLoS ONE 8(5): e63970.)
V5-TAG, Monoclonal Antibody (Cat# AAA212109)
Full Name
MOUSE ANTI V5-TAG
Applications
EIA, FC/FACS, IF, IP, WB, RIA
Pricing
$785/1 mg | $3,370/5x1 mg
Testing Data
(Published customer image: Mouse anti V5 tag antibody, clone SV5-Pk1 used for detection of V5 tagged REDD1 protein by western blotting.Image caption:REDD1 is not degraded by Cul4a or phosphorylated by GSK3beta at Thr 23 and Thr25. (A) HEK293 cells were transfected with empty vector or tetracycline inducible dnCul4a-V5 pcDNA4/TO (1 ug) and Cul4A-V5 pcDNA3 (0.03 ug) followed by tetracycline (1 ug/ml) induction for 24 hours and cell lysis. (B) HEK293 cells were transfected with 0.5 ug Cul4a-V5 pcDNA3 for 15 hours followed by transfection of 20 nM control or Cul4a siRNAs to determine siRNAs efficiency. (C) HEK293 cells were transfected with 20 nM control or Cul4a siRNAs for 3 days followed by cell lysis. (D) REDD1-V5 pcDNA3 wild type, T23A T25A or T23D T25D plasmids (0.4 ug) were transfected in HEK293 cells for 3 days and treated with 20 uM MG-132 for 6 hours followed by cell lysis. (E) HEK293 cells were treated with 30 mM LiCl or GSK3 inhibitor IX (5 uM or 10 uM) for 20 hours followed by cell lysis. (F) HEK293 cells were co-transfected with 0.2 ug REDD1-V5 pcDNA3 and 0.3 ug GSK3beta pcDNA3 or empty pcDNA3 for 3 days followed by MG-132 (20 uM) treatment for 6 hours followed by cell lysis. (G) HEK293 cells were transfected with 3 ug DYKDDDDK-REDD1 or DYKDDDDK-FRAT1 for 3 days followed by cell lysis and DYKDDDDK immunoprecipitation. In vitro phosphorylation of REDD1 and FRAT1 was carried out as described in Materials and Methods..From: Tan CY, Hagen T (2013) mTORC1 Dependent Regulation of REDD1 Protein Stability. PLoS ONE 8(5): e63970.)
V5-TAG, Monoclonal Antibody (Cat# AAA210328)
Full Name
MOUSE ANTI V5-TAG:Biotin
Applications
EIA, WB
Pricing
$445/0.1 mg | $1,845/5x0.1 mg
Testing Data
(Published customer image: Mouse anti V5 tag antibody, clone SV5-Pk1 used for detection of V5 tagged REDD1 protein by western blotting.Image caption:REDD1 is not degraded by Cul4a or phosphorylated by GSK3beta at Thr 23 and Thr25. (A) HEK293 cells were transfected with empty vector or tetracycline inducible dnCul4a-V5 pcDNA4/TO (1 ug) and Cul4A-V5 pcDNA3 (0.03 ug) followed by tetracycline (1 ug/ml) induction for 24 hours and cell lysis. (B) HEK293 cells were transfected with 0.5 ug Cul4a-V5 pcDNA3 for 15 hours followed by transfection of 20 nM control or Cul4a siRNAs to determine siRNAs efficiency. (C) HEK293 cells were transfected with 20 nM control or Cul4a siRNAs for 3 days followed by cell lysis. (D) REDD1-V5 pcDNA3 wild type, T23A T25A or T23D T25D plasmids (0.4 ug) were transfected in HEK293 cells for 3 days and treated with 20 uM MG-132 for 6 hours followed by cell lysis. (E) HEK293 cells were treated with 30 mM LiCl or GSK3 inhibitor IX (5 uM or 10 uM) for 20 hours followed by cell lysis. (F) HEK293 cells were co-transfected with 0.2 ug REDD1-V5 pcDNA3 and 0.3 ug GSK3beta pcDNA3 or empty pcDNA3 for 3 days followed by MG-132 (20 uM) treatment for 6 hours followed by cell lysis. (G) HEK293 cells were transfected with 3 ug DYKDDDDK-REDD1 or DYKDDDDK-FRAT1 for 3 days followed by cell lysis and DYKDDDDK immunoprecipitation. In vitro phosphorylation of REDD1 and FRAT1 was carried out as described in Materials and Methods..From: Tan CY, Hagen T (2013) mTORC1 Dependent Regulation of REDD1 Protein Stability. PLoS ONE 8(5): e63970.)
V5-TAG, Monoclonal Antibody (Cat# AAA214958)
Full Name
MOUSE ANTI V5-TAG:HRP
Applications
EIA, WB
Pricing
$490/0.1 mg | $2,060/5x0.1 mg
Testing Data
(Published customer image: Mouse anti V5 tag antibody, clone SV5-Pk1 used for detection of V5 tagged REDD1 protein by western blotting.Image caption:REDD1 is not degraded by Cul4a or phosphorylated by GSK3beta at Thr 23 and Thr25. (A) HEK293 cells were transfected with empty vector or tetracycline inducible dnCul4a-V5 pcDNA4/TO (1 ug) and Cul4A-V5 pcDNA3 (0.03 ug) followed by tetracycline (1 ug/ml) induction for 24 hours and cell lysis. (B) HEK293 cells were transfected with 0.5 ug Cul4a-V5 pcDNA3 for 15 hours followed by transfection of 20 nM control or Cul4a siRNAs to determine siRNAs efficiency. (C) HEK293 cells were transfected with 20 nM control or Cul4a siRNAs for 3 days followed by cell lysis. (D) REDD1-V5 pcDNA3 wild type, T23A T25A or T23D T25D plasmids (0.4 ug) were transfected in HEK293 cells for 3 days and treated with 20 uM MG-132 for 6 hours followed by cell lysis. (E) HEK293 cells were treated with 30 mM LiCl or GSK3 inhibitor IX (5 uM or 10 uM) for 20 hours followed by cell lysis. (F) HEK293 cells were co-transfected with 0.2 ug REDD1-V5 pcDNA3 and 0.3 ug GSK3beta pcDNA3 or empty pcDNA3 for 3 days followed by MG-132 (20 uM) treatment for 6 hours followed by cell lysis. (G) HEK293 cells were transfected with 3 ug DYKDDDDK-REDD1 or DYKDDDDK-FRAT1 for 3 days followed by cell lysis and DYKDDDDK immunoprecipitation. In vitro phosphorylation of REDD1 and FRAT1 was carried out as described in Materials and Methods..From: Tan CY, Hagen T (2013) mTORC1 Dependent Regulation of REDD1 Protein Stability. PLoS ONE 8(5): e63970.)
V5-TAG, Monoclonal Antibody (Cat# AAA210664)
Full Name
MOUSE ANTI V5-TAG:FITC
Applications
IF
Pricing
$445/0.1 mg | $1,845/5x0.1 mg
Testing Data
(Published customer image: Mouse anti V5 tag antibody, clone SV5-Pk1 used for detection of V5 tagged REDD1 protein by western blotting.Image caption:REDD1 is not degraded by Cul4a or phosphorylated by GSK3beta at Thr 23 and Thr25. (A) HEK293 cells were transfected with empty vector or tetracycline inducible dnCul4a-V5 pcDNA4/TO (1 ug) and Cul4A-V5 pcDNA3 (0.03 ug) followed by tetracycline (1 ug/ml) induction for 24 hours and cell lysis. (B) HEK293 cells were transfected with 0.5 ug Cul4a-V5 pcDNA3 for 15 hours followed by transfection of 20 nM control or Cul4a siRNAs to determine siRNAs efficiency. (C) HEK293 cells were transfected with 20 nM control or Cul4a siRNAs for 3 days followed by cell lysis. (D) REDD1-V5 pcDNA3 wild type, T23A T25A or T23D T25D plasmids (0.4 ug) were transfected in HEK293 cells for 3 days and treated with 20 uM MG-132 for 6 hours followed by cell lysis. (E) HEK293 cells were treated with 30 mM LiCl or GSK3 inhibitor IX (5 uM or 10 uM) for 20 hours followed by cell lysis. (F) HEK293 cells were co-transfected with 0.2 ug REDD1-V5 pcDNA3 and 0.3 ug GSK3beta pcDNA3 or empty pcDNA3 for 3 days followed by MG-132 (20 uM) treatment for 6 hours followed by cell lysis. (G) HEK293 cells were transfected with 3 ug DYKDDDDK-REDD1 or DYKDDDDK-FRAT1 for 3 days followed by cell lysis and DYKDDDDK immunoprecipitation. In vitro phosphorylation of REDD1 and FRAT1 was carried out as described in Materials and Methods..From: Tan CY, Hagen T (2013) mTORC1 Dependent Regulation of REDD1 Protein Stability. PLoS ONE 8(5): e63970.)
V5-TAG, Monoclonal Antibody (Cat# AAA216888)
Full Name
MOUSE ANTI V5-TAG
Applications
EIA, FC/FACS, IF, IP, WB, RIA
Pricing
$1,350/2 mg | $5,915/5x2 mg
Immunohistochemistry (IHC)
(Anti-DNA-PKcs antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)
PRKDC / DNA-PKcs, Polyclonal Antibody (Cat# AAA240528)
Full Name
Rabbit Polyclonal to Human PRKDC / DNA-PKcs
Gene Names
PRKDC; HYRC; p350; DNAPK; DNPK1; HYRC1; IMD26; XRCC7; DNA-PKcs
Reactivity
Chimpanzee, Human
Applications
IHC - Paraffin, WB, EIA
Purity
Immunoaffinity Purified
Pricing
$640/0.05 mg | $2,815/5x0.05 mg
Structure
Torin 1, Inhibitor (Cat# AAA578620)
Full Name
Torin 1
Purity
98.3%
Pricing
$195/2 mg | $215/5 mg | $250/10 mg | $390/25 mg | $525/50 mg | $785/100 mg | $3,260/5x100 mg
Structure
NU7441, Inhibitor (Cat# AAA578838)
Full Name
NU7441
Purity
99.87%
Pricing
$185/2 mg | $205/5 mg | $235/10 mg | $315/25 mg | $405/50 mg | $525/100 mg | $765/200 mg | $3,180/5x200 mg
Testing Data
(PP242 is a novel potent and selective mTOR inhibitor with an IC50 of 8 nM. PP242 also shows residual (micromolar) activity against panel of tyrosine kinases. But PP242 was much less active against other PI3K family members with IC50 of 2, 2.2, 0.1, 1.3 and 0.41 uM for p110alpha, p110beta, p110delta, p110gamma and DNA-PK, respectively. PP242 inhibits other PI 3-Kinases only at much higher concentrations. PP242, but not rapamycin, causes death of mouse and human leukemia cells. In vivo, PP242 delays leukemia onset and augments the effects of the current front-line tyrosine kinase inhibitors more effectively than does rapamycin. PP242 was also more effective than rapamycin in achieving cytoreduction and apoptosis in multiple myeloma cells. In addition, PP242 was an effective agent against primary multiple myeloma cells in vitro and growth of 8226 cells in mice. Knockdown of the TORC2 complex protein, rictor, was deleterious to multiple myeloma cells further supporting TORC2 as the critical target for PP242. [1][2][3])
Testing Data
(PI-103 is a potent, cell-permeable, ATP-competitive PI3K family members inhibitor with IC50 of 2, 8, 20, 26, 48, 83, 88, 150 nM for DNA-PK, p110alpha, mTORC1, PI3-KC2beta, p110delta, mTORC2, p110beta, and p110gamma, respectively. It shows little activity against a wide array of protein kinases at 10 mM. It blocks glioma proliferation by blocking the PI 3-K/Akt pathway in vitro and in vivo. PI-103 was essentially cytostatic for cell lines and induced cell cycle arrest in the G1 phase. In blast cells, PI-103 inhibited leukemic proliferation, the clonogenicity of leukemic progenitors and induced mitochondrial apoptosis, especially in the compartment containing leukemic stem cells. PI-103 had additive proapoptotic effects with etoposide in blast cells and in immature leukemic cells. [1][2][3])
Structure
Talazoparib, Inhibitor (Cat# AAA578816)
Full Name
Talazoparib (BMN 673)
Purity
99.42%
Pricing
$180/1 mg | $190/2 mg | $210/5 mg | $230/10 mg | $265/25 mg | $330/50 mg | $440/100 mg | $560/200 mg | $210/1 mL (in DMSO) | $2,250/5x200 mg
Testing Data
(PP121 is a multitargeted dual receptor tyrosine kinases inhibitor with IC50 of 0.052, 1.4, 0.15, 1.1, 0.06, 0.01and 0.002 uM for p110alpha, p110beta, p110delta, p110gamma, DNA-PK, mTOR and PDGFR, respectively. PP121 also inhibits Abl, Hck, Src,Src(T338I), VEGFR2, EGFR EphB4 with IC50 of 0.018, 0.008, 0.014, 0.22, 0.012, 0.26, 0.19 uM, respectively. PP121 exhibits no significant effect on receptor serine/threonine kinases (RSTKs). PP121 blocks the proliferation of tumor cells by direct inhibition of PI 3-K, mTOR, Src and the VEGF receptor. PP121 achieves its dual potency by targeting a residue (Glu310 in Src) that has been structurally conserved between kinase families. PP121 potently and dose-dependently blocked the phosphorylation of Akt, p70S6K and S6 in these cells. [1])
Structure
SF2523, Inhibitor (Cat# AAA579900)
Full Name
SF2523
Purity
97.8%
Pricing
$205/1 mg | $270/5 mg | $355/10 mg | $570/25 mg | $255/1 mL (in DMSO) | $2,295/5x25 mg
Structure
PI-103, Inhibitor (Cat# AAA578711)
Full Name
PI-103
Purity
97.59%
Pricing
$205/5 mg | $210/10 mg | $265/25 mg | $330/50 mg | $490/100 mg | $745/200 mg | $205/1 mL (in DMSO) | $3,080/5x200 mg
CC-115, Inhibitor (Cat# AAA579664)
Full Name
CC-115
Purity
95.0%
Pricing
$205/2 mg | $225/5 mg | $280/10 mg | $455/25 mg | $575/50 mg | $835/100 mg | $225/1 mL (in DMSO) | $3,495/5x100 mg
Structure
KU-0060648, Inhibitor (Cat# AAA579098)
Full Name
KU-0060648
Purity
98.0%
Pricing
$260/2 mg | $315/5 mg | $810/25 mg | $3,370/5x25 mg
Wortmannin, Inhibitor (Cat# AAA5750129)
Full Name
Wortmannin
Purity
98.00%
Pricing
$200/2 mg | $215/5 mg | $235/10 mg | $310/25 mg | $355/50 mg | $420/100 mg | $225/1 mL (in DMSO) | $1,625/5x100 mg
Compound 401, Inhibitor (Cat# AAA579701)
Full Name
Compound 401
Purity
99.8%
Pricing
$205/2 mg | $225/5 mg | $245/10 mg | $335/25 mg | $490/50 mg | $745/100 mg | $230/1 mL (in DMSO) | $3,085/5x100 mg
Chemical Structure
YU238259, Inhibitor (Cat# AAA5750475)
Full Name
YU238259
Purity
99.4%
Pricing
$205/2 mg | $240/5 mg | $300/10 mg | $455/25 mg | $710/50 mg | $1,080/100 mg | $245/1 mL (in DMSO) | $4,600/5x100 mg
Structure
KU-55933, Inhibitor (Cat# AAA3605167)
Full Name
KU-55933
Purity
>98% (HPLC)
Pricing
$200/5 mg | $210/10 mg | $295/25 mg | $335/50 mg | $410/100 mg | $1,555/5x100 mg
Structure
Pictilisib dimethanesulfonate, Inhibitor (Cat# AAA5753177)
Full Name
Pictilisib dimethanesulfonate
Purity
98.00%
Pricing
$200/5 mg | $215/10 mg | $265/25 mg | $325/50 mg | $400/100 mg | $550/200 mg | $230/1 mL (in DMSO) | $2,210/5x200 mg
Structure
Torin1, Inhibitor (Cat# AAA3600848)
Full Name
Torin1
Purity
>98% (HPLC)
Pricing
$190/2 mg | $210/5 mg | $245/10 mg | $370/25 mg | $485/50 mg | $715/100 mg | $2,945/5x100 mg
Structure
LY294002, Inhibitor (Cat# AAA3602191)
Full Name
LY294002
Purity
>98% (HPLC)
Pricing
$175/5 mg | $185/10 mg | $200/50 mg | $210/100 mg | $240/200 mg | $795/5x200 mg
Structure
(R)-(-)-Rolipram, Inhibitor (Cat# AAA5754196)
Full Name
(R)-(-)-Rolipram
Purity
98.00%
Pricing
$230/10 mg | $425/50 mg | $240/1mL*10mM (in DMSO) | $1,635/5x50 mg
Structure
PI3K inhibitor X, Inhibitor (Cat# AAA3606827)
Full Name
PI3K inhibitor X
Purity
>98% (HPLC)
Pricing
$200/2 mg | $230/5 mg | $315/25 mg | $390/50 mg | $600/100 mg | $785/200 mg | $3,225/5x200 mg
Structure
CC-115, Inhibitor (Cat# AAA3600883)
Full Name
CC-115
Purity
>98% (HPLC)
Pricing
$200/2 mg | $215/5 mg | $275/10 mg | $425/25 mg | $535/50 mg | $765/100 mg | $3,155/5x100 mg
Structure
PP 242, Inhibitor (Cat# AAA3600346)
Full Name
PP 242
Purity
>98% (HPLC)
Pricing
$200/5 mg | $210/10 mg | $245/25 mg | $260/50 mg | $330/100 mg | $415/200 mg | $1,590/5x200 mg
Structure
SF2523, Inhibitor (Cat# AAA3600593)
Full Name
SF2523
Purity
>98% (HPLC)
Pricing
$260/5 mg | $335/10 mg | $530/25 mg | $2,095/5x25 mg
Structure
LY3023414, Inhibitor (Cat# AAA3601608)
Full Name
LY3023414
Purity
>98% (HPLC)
Pricing
$210/2 mg | $235/5 mg | $300/10 mg | $420/25 mg | $1,605/5x25 mg
Structure
Structure
Compound 401, Inhibitor (Cat# AAA3602571)
Full Name
Compound 401
Purity
>98% (HPLC)
Pricing
$190/2 mg | $225/5 mg | $250/10 mg | $375/25 mg | $520/50 mg | $820/100 mg | $3,400/5x100 mg
Structure
Leniolisib, Inhibitor (Cat# AAA5751611)
Full Name
Leniolisib
Purity
99.97%
Pricing
$230/1 mg | $295/5 mg | $400/10 mg | $690/25 mg | $1,080/50 mg | $1,760/100 mg | $7,650/5x100 mg
Structure
PIK-93, Inhibitor (Cat# AAA3605200)
Full Name
PIK-93
Purity
>98% (HPLC)
Pricing
$190/2 mg | $220/5 mg | $275/10 mg | $395/25 mg | $1,475/5x25 mg
Structure
OSI-027, Inhibitor (Cat# AAA3606705)
Full Name
OSI-027
Purity
>98% (HPLC)
Pricing
$230/5 mg | $305/10 mg | $580/50 mg | $2,305/5x50 mg
Structure
AZD-7648, Inhibitor (Cat# AAA5752340)
Full Name
AZD-7648
Purity
98.00%
Pricing
$210/2 mg | $235/5 mg | $270/10 mg | $365/25 mg | $485/50 mg | $665/100 mg | $240/1 mL (in DMSO) | $2,715/5x100 mg
Structure
Structure
NU7026, Inhibitor (Cat# AAA3602190)
Full Name
NU7026
Purity
>98% (HPLC)
Pricing
$200/5 mg | $215/10 mg | $295/25 mg | $405/50 mg | $590/100 mg | $2,350/5x100 mg
Structure
(Rac)-Nedisertib, Inhibitor (Cat# AAA5753796)
Full Name
(Rac)-Nedisertib
Purity
98.00%
Pricing
$290/5 mg | $365/10 mg | $550/25 mg | $800/50 mg | $1,225/100 mg | $305/1mL*10mM (in DMSO) | $5,240/5x100 mg
Structure
Structure
NU-6027, Inhibitor (Cat# AAA3603509)
Full Name
NU-6027
Purity
>98% (HPLC)
Pricing
$200/5 mg | $235/10 mg | $280/25 mg | $370/50 mg | $565/100 mg | $2,245/5x100 mg
Structure
CC-223, Inhibitor (Cat# AAA3600884)
Full Name
CC-223
Purity
>98% (HPLC)
Pricing
$210/2 mg | $235/5 mg | $295/10 mg | $420/25 mg | $670/50 mg | $2,735/5x50 mg
Structure
(R)-Nedisertib, Inhibitor (Cat# AAA5754193)
Full Name
(R)-Nedisertib
Purity
98.00%
Pricing
$345/5 mg | $425/10 mg | $685/25 mg | $935/50 mg | $365/1mL*10mM (in DMSO) | $3,925/5x50 mg
Structure
ETP46464, Inhibitor (Cat# AAA3601386)
Full Name
ETP46464
Purity
>98% (HPLC)
Pricing
$205/2 mg | $230/5 mg | $285/10 mg | $445/25 mg | $645/50 mg | $2,610/5x50 mg
Structure
PI3K-IN-1, Inhibitor (Cat# AAA3601414)
Full Name
PI3K-IN-1
Purity
>98% (HPLC)
Pricing
$190/2 mg | $230/5 mg | $280/10 mg | $445/25 mg | $645/50 mg | $2,610/5x50 mg
Structure
AZD 6482, Inhibitor (Cat# AAA3600586)
Full Name
AZD 6482
Purity
>98% (HPLC)
Pricing
$225/2 mg | $265/5 mg | $355/10 mg | $565/25 mg | $870/50 mg | $3,620/5x50 mg
Structure
Wortmannin, Inhibitor (Cat# AAA3603060)
Full Name
Wortmannin
Purity
>98% (HPLC)
Pricing
$190/2 mg | $210/5 mg | $245/10 mg | $335/25 mg | $485/50 mg | $775/100 mg | $3,200/5x100 mg
Structure
Structure
KU-57788, Inhibitor (Cat# AAA3604706)
Full Name
KU-57788
Purity
>98% (HPLC)
Pricing
$205/5 mg | $230/10 mg | $305/25 mg | $380/50 mg | $485/100 mg | $705/200 mg | $2,890/5x200 mg
Structure
Torin2, Inhibitor (Cat# AAA3600851)
Full Name
Torin2
Purity
>98% (HPLC)
Pricing
$190/2 mg | $215/5 mg | $245/10 mg | $370/25 mg | $430/50 mg | $580/100 mg | $2,325/5x100 mg
Structure
