Structure
LY294002, Inhibitor
LY294002
Purity
>98% (HPLC)
Synonyms
LY294002; NSC 697286; SF 1101; LY 294002; LY-294002; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: 14.9mg/mL
Target
PI3K
Receptor
p110alpha; p110beta; p110delta; DNA-PK
Chemical Name
4H-1-Benzopyran-4-one, 2-(4-morpholinyl)-8-phenyl
SMILES
O=C1C=C(N2CCOCC2)OC3=C(C4=CC=CC=C4)C=CC=C13
Molecular Formula
C19H17NO3
CAS Number
154447-36-6
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for LY294002, inhibitor
A classic, broad-spectrum PI3K inhibitor with IC50 of 0.5/0.57/0.97uM for PI3Kalpha/delta/beta, respectively; completely and specifically abolishes PI3K activity (IC50=1.4uM), but does not inhibit PI4K or other lipid kinases; demonstrates growth-inhibitory and apoptosis-inducing effect in colon cancer cell lines, with decreased phosphorylated Akt Ser (473); suppresses tumor growth in mouse xenografts; also is a potent inhibitor of CK2 with IC50 of 98nM.
Product Categories/Family for LY294002, inhibitor
References
1. Vlahos CJ, et al. J Biol Chem. 1994 Feb 18; 269 (7):5241-8.
2. Cheatham B, et al. Mol Cell Biol. 1994 Jul; 14 (7):4902-11.
3. Semba S, et al. Clin Cancer Res. 2002 Jun; 8 (6):1957-63.
4. Gharbi SI, et al. Biochem J. 2007 May 15; 404 (1):15-21.
2. Cheatham B, et al. Mol Cell Biol. 1994 Jul; 14 (7):4902-11.
3. Semba S, et al. Clin Cancer Res. 2002 Jun; 8 (6):1957-63.
4. Gharbi SI, et al. Biochem J. 2007 May 15; 404 (1):15-21.
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Product Notes
The LY294002 (Catalog #AAA3602191) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "LY294002, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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