Syndecan-4 Recombinant Protein | Sdc4 recombinant protein

Recombinant Mouse Syndecan-4 Protein

Cat. Num. AAA2556763

• Gene Names: Sdc4; S4; Synd4; AA959608; AW108331; ryudocan; syndecan-4
• Purity: >95% as determined by reducing SDS-PAGE.
• Synonyms: Syndecan-4; Recombinant Mouse Syndecan-4 Protein; SDC4; SYND4; Ryudocan core protein; Sdc4 recombinant protein

• Host: Human Cells
• Purity/Purification: >95% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 mum filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
• Sequence Length: 198

• Species: Mouse
• Endotoxin: <1.0 EU per mug as determined by LAL test.
• Fragment: Met 1-Val 146
• Fusion Tag: C-6His
• Preparation and Storage: Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks.; Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days.; Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

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Related Product Information for Sdc4 recombinant protein

Protein Construction: Recombinant Mouse Syndecan-4 is produced by our Mammalian expression system and the target gene encoding Glu24-Glu145 is expressed with a 6His tag at the C-terminus.

Background: Mouse SDC4 is a ubiquitous transmembrane proteoglycan which belongs to the syndecan proteoglycan family. SDC4 is a cell surface proteoglycan that bears heparan sulfate. The four vertebrate syndecans, Syndecan-1 through -4, have similar short cytoplasmic domains and extracellular portions that diverge, except for HS attachment sites. Structurally diverse side chains add considerably to the size of the core proteins and serve as binding sites for growth factors, cytokines, and extracellular matrix proteins. Syndecans are present as homodimers or multimers, and are often expressed in developmental and cell type-specific patterns. It is expressed highly in liver, kidney and lung. SDC4 localizes to the focal adhesions of adherent cells and binds to a range of extracellular ligands, including growth factors and extracellular-matrix proteins. Through its extracellular domain, syndecan-4 cooperates with adhesion molecules and binds matrix components relevant for cell migration. As a heparan sulfate proteoglycan, SDC4 works as a coreceptor for various growth factors. Syn4 deficiency limits neointimal formation after vascular injury by regulating vascular smooth muscle cells (VSMCs) proliferation and vascular progenitor cells (VPCs) mobilization. SDC4 have an array of functions including regulating cell growth, differentiation, and adhesion.

NCBI and Uniprot Product Information

• NCBI GI #: 6755442
• NCBI GeneID: 20971
• NCBI Accession #: NP_035651.1
• NCBI GenBank Nucleotide #: NM_011521.2
• UniProt Accession #: O35988
• Molecular Weight: Molecular Mass: 14.4kDa; Actual Protein Molecular Mass: 24kDa
• NCBI Official Full Name: syndecan-4
• NCBI Official Synonym Full Names: syndecan 4
• NCBI Official Symbol: Sdc4
• NCBI Official Synonym Symbols: S4; Synd4; AA959608; AW108331; ryudocan; syndecan-4
• NCBI Protein Information: syndecan-4
• UniProt Protein Name: Syndecan-4
• Protein Family: Syndecan
• UniProt Gene Name: Sdc4
• UniProt Synonym Gene Names: SYND4

Uniprot Description

Cell surface proteoglycan that bears heparan sulfate. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP.