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Immunohistochemistry (IHC) (Immunohistochemistry of paraffin-embedded human breast cancer using MBS7602289 (OXTR antibody) at dilution of 1:50)

Rabbit anti-Human, Mouse Oxytocin Receptor Polyclonal Antibody | anti-OXTR antibody

Oxytocin Receptor Rabbit Polyclonal Antibody

Gene Names
OXTR; OT-R
Reactivity
Human, Mouse
Applications
ELISA, Western Blot, Immunohistochemistry, Flow Cytometry
Purity
Purification: Immunogen affinity purified
Purity: > 95% as determined by SDS-PAGE
Synonyms
Oxytocin Receptor; Polyclonal Antibody; Oxytocin Receptor Rabbit Polyclonal Antibody; OT R; OXTR; anti-OXTR antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Purification: Immunogen affinity purified
Purity: > 95% as determined by SDS-PAGE
Form/Format
Liquid
Sequence Length
389
Applicable Applications for anti-OXTR antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Flow Cytometry (FC)
Application Notes
WB:1:500-1:2000
IP:1:500-1:2000
IHC:1:20-1:200
Immunogen
Oxytocin receptor
Buffer
PBS with 0.02% sodium azide and 50% glycerol pH 7.3
Preparation and Storage
Store at -20°C. Avoid repeated freeze / thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human breast cancer using MBS7602289 (OXTR antibody) at dilution of 1:50)

Immunohistochemistry (IHC) (Immunohistochemistry of paraffin-embedded human breast cancer using MBS7602289 (OXTR antibody) at dilution of 1:50)

Western Blot (WB)

(Jurkat cells were subjected to SDS PAGE followed by western blot with MBS7602289 (OXTR antibody) at dilution of 1:1000)

Western Blot (WB) (Jurkat cells were subjected to SDS PAGE followed by western blot with MBS7602289 (OXTR antibody) at dilution of 1:1000)
Related Product Information for anti-OXTR antibody
Oxytocin (OXT) is a neurohypophysial hormone that plays a role in lactation and parturition and in the central nervous system as a neurotransmitter involved in sex and maternal behavior (PMID: 1852313; 10811917). Oxytocin acts through its receptor, OXTR, which belongs to the G protein-coupled 7-transmembrane receptor family. OXTR is expressed in endometrium, myometrium, mammary gland (PMID: 1313946). This antibody is raised against the C-terminal region of human OXTR.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
Observed MW: 45 kDa
NCBI Official Full Name
oxytocin receptor
NCBI Official Synonym Full Names
oxytocin receptor
NCBI Official Symbol
OXTR
NCBI Official Synonym Symbols
OT-R
NCBI Protein Information
oxytocin receptor
UniProt Protein Name
Oxytocin receptor
Protein Family
UniProt Gene Name
OXTR
UniProt Synonym Gene Names
OT-R
UniProt Entry Name
OXYR_HUMAN

NCBI Description

The protein encoded by this gene belongs to the G-protein coupled receptor family and acts as a receptor for oxytocin. Its activity is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. The oxytocin-oxytocin receptor system plays an important role in the uterus during parturition. [provided by RefSeq, Jul 2008]

Uniprot Description

OXTR: Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol- calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.

Protein type: GPCR, family 1; Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR

Chromosomal Location of Human Ortholog: 3p25

Cellular Component: apical plasma membrane; cell-cell adherens junction; cytosol; integral to plasma membrane; microvillus; plasma membrane

Molecular Function: oxytocin receptor activity; peptide binding; peptide hormone binding; vasopressin receptor activity

Biological Process: cell surface receptor linked signal transduction; cellular response to hormone stimulus; eating behavior; elevation of cytosolic calcium ion concentration; female pregnancy; G-protein coupled receptor protein signaling pathway; gut development; heart development; lactation; maternal behavior; maternal process involved in parturition; memory; muscle contraction; positive regulation of blood pressure; positive regulation of synaptic transmission, GABAergic; positive regulation of synaptic transmission, glutamatergic; positive regulation of synaptogenesis; positive regulation of vasoconstriction; regulation of systemic arterial blood pressure by vasopressin; response to amphetamine; response to anoxia; response to cocaine; response to cytokine stimulus; response to drug; response to estradiol stimulus; response to peptide hormone stimulus; response to progesterone stimulus; sleep; social behavior; sperm ejaculation; suckling behavior; telencephalon development

Research Articles on OXTR

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Product Notes

The OXTR oxtr (Catalog #AAA7602289) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Oxytocin Receptor Rabbit Polyclonal Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Oxytocin Receptor can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Flow Cytometry (FC). WB:1:500-1:2000 IP:1:500-1:2000 IHC:1:20-1:200. Researchers should empirically determine the suitability of the OXTR oxtr for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Oxytocin Receptor, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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