Rabbit TLR8 Polyclonal Antibody | anti-TLR8 antibody

TLR8 Antibody

Cat. Num. AAA841238

• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: Affinity purified
• Synonyms: TLR8; Polyclonal Antibody; TLR8 Antibody; LR8; Anti-TLR8; CD288; CD 288; MGC119599; # MGC119600; anti-TLR8 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity purified
• Form/Format: 100 ug (0.5 mg/ml) affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.; Appearance: Colorless liquid
• Concentration: 0.5 mg/ml (varies by lot)
• Sequence Length: 1032

• Applicable Applications for anti-TLR8 antibody: Western Blot (WB)
• Application Notes: Western blotting (0.5-4 ug/ml). However, the optimal conditions should be determined individually. The antibody recognizes ~120 kDa TLR8 in samples from human, mouse and rat origins. Reactivity to other species has not been tested.
• Immunogen: Synthetic peptide surrounding amino acid 942of mouse TLR8
• Handling: The antibody solution should be gently mixed before use.
• Preparation and Storage: At -20 degree C; Shelf Life: 12 months

Testing Data

Related Product Information for anti-TLR8 antibody

Background: The Toll-like receptor (TLR) family in mammalian comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Up-to-date, ten TLRs (TLR1-10) have been described.TLR8 gene contains three exons, two of which have coding function. Expression of TLR receptors is highest in peripheral blood leukocytes, macrophages, and monocytes.

NCBI and Uniprot Product Information

• NCBI GI #: 126723495
• NCBI GeneID: 170744
• NCBI Accession #: NP_573475
• NCBI GenBank Nucleotide #: NM_133212.2
• Molecular Weight: 119,358 Da
• NCBI Official Full Name: toll-like receptor 8
• NCBI Official Synonym Full Names: toll-like receptor 8
• NCBI Official Symbol: Tlr8
• NCBI Protein Information: toll-like receptor 8
• UniProt Protein Name: Toll-like receptor 8
• Protein Family: Toll-like receptor
• UniProt Gene Name: Tlr8
• UniProt Entry Name: TLR8_MOUSE

Uniprot Description

TLR8: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Belongs to the Toll-like receptor family.

Protein type: Receptor, misc.; Membrane protein, integral

Cellular Component: membrane; integral to membrane; intracellular

Molecular Function: single-stranded RNA binding; DNA binding; double-stranded RNA binding; drug binding

Biological Process: I-kappaB kinase/NF-kappaB cascade; regulation of cytokine secretion; regulation of protein amino acid phosphorylation; immune system process; response to virus; positive regulation of interleukin-8 biosynthetic process; microglial cell activation; positive regulation of interferon-alpha biosynthetic process; toll-like receptor 8 signaling pathway; signal transduction; MyD88-dependent toll-like receptor signaling pathway; positive regulation of innate immune response; positive regulation of interferon-beta biosynthetic process; toll-like receptor signaling pathway; innate immune response; inflammatory response; defense response to virus; positive regulation of interferon-gamma biosynthetic process