Immunohistochemistry (IHC)
(Immunochemical staining of human RNF112 in human kidney with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.)
Rabbit anti-Human RNF112 Polyclonal Antibody | anti-RNF112 antibody
Anti-RNF112 Antibody, Rabbit Polyclonal
Reactivity
Human
Applications
Immunohistochemistry
Purity
Protein A & Antigen Affinity
Synonyms
RNF112; Polyclonal Antibody; Anti-RNF112 Antibody; Rabbit Polyclonal; RNF112 Antibody; Rabbit PAb; Antigen Affinity Purified; Anti-BFP Antibody; Anti-ZNF179 Antibody; anti-RNF112 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
Human RNF112
Purity/Purification
Protein A & Antigen Affinity
Form/Format
Liquid; PBS, pH7.0 with 0.03% Proclin300
Applicable Applications for anti-RNF112 antibody
Immunohistochemistry-Paraffin (IHC-P)
Application Notes
IHC-P: 1:50-1:200
Immunogen
E Coli-derived Human RNF112 fragment
Conjugation
Unconjugated
Preparation
Produced in rabbits immunized with E Coli-derived Human RNF112 fragment, and purified by antigen affinity chromatography.
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Avoid repeated freeze-thaw cycles.
Immunohistochemistry (IHC)
(Immunochemical staining of human RNF112 in human kidney with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.)
Immunohistochemistry (IHC)
(Immunochemical staining of human RNF112 in human kidney with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.)
Related Product Information for anti-RNF112 antibody
Rnf112, also known as Znf179, is a member of the RING finger protein family. Znf179 protein has a characteristic C3HC4-type Zinc-finger motif located in the N-terminus. The expression of Rnf112 is abundant in the brain and is modulated during brain progression and development. The human ZNF179 gene is located on chromosome 17p11.2 and is present in the Smith-Magenis syndrome (SMS) common deletion region. ZNF179 is considered to be one of the candidate genes for SMS, which is a complex neuropediatric-neurobehavioral syndrome. Znf179 is significantly down-regulated in neurodegenerative diseases such as Huntington's disease (HD) and amyotrophic lateral sclerosis (ALS), implying that Znf179 may associate with neurodegenerative diseases.
References
Zhang F, et al. (2018) Rnf112 deletion protects brain against intracerebral hemorrhage (ich) in mice by inhibiting tlr-4/nf-kappab pathway. Biochem Biophys Res Commun 507 (1-4): 43-50.Tsou JH, et al. (2017) Important roles of ring finger protein 112 in embryonic vascular development and brain functions. Mol Neurobiol 54 (3): 2286-2300.Lin DY, et al. (2013) Analysis of the interaction between zinc finger protein 179 (znf179) and promyelocytic leukemia zinc finger (plzf). J Biomed Sci 20 (1): 98.
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Product Notes
The RNF112 (Catalog #AAA8109950) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-RNF112 Antibody, Rabbit Polyclonal reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's RNF112 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry-Paraffin (IHC-P). IHC-P: 1:50-1:200. Researchers should empirically determine the suitability of the RNF112 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "RNF112, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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