Rabbit anti-Human TTBK1 Polyclonal Antibody | anti-TTBK1 antibody

Anti-TTBK1 Antibody, Rabbit Polyclonal

Cat. Num. AAA8110158

• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Protein A & Antigen Affinity
• Synonyms: TTBK1; Polyclonal Antibody; Anti-TTBK1 Antibody; Rabbit Polyclonal; TTBK1 Antibody; Rabbit PAb; Antigen Affinity Purified; Anti-BDTK Antibody; Anti-RP3-330M21.4 Antibody; anti-TTBK1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: Human TTBK1
• Purity/Purification: Protein A & Antigen Affinity
• Form/Format: Liquid; PBS, pH7.0 with 0.03% Proclin300

• Applicable Applications for anti-TTBK1 antibody: Immunohistochemistry-Paraffin (IHC-P)
• Application Notes: IHC-P: 1:50-1:200
• Immunogen: E Coli-derived Human TTBK1 fragment
• Conjugation: Unconjugated
• Preparation: Produced in rabbits immunized with E Coli-derived Human TTBK1 fragment, and purified by antigen affinity chromatography.
• Preparation and Storage: This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Avoid repeated freeze-thaw cycles.

Immunohistochemistry (IHC)

(Immunochemical staining of human TTBK1 in human brain with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.)

Related Product Information for anti-TTBK1 antibody

Tau-tubuline kinases (TTBK) are a family of serine/threonine and tyrosine kinases recently discovered and implicated in the phosphorylation of important substrates such as tau, tubuline or TDP-43. Its two homologs, TTBK1 and TTBK2, show different expression patterns and different involvements in physiological mechanisms of great importance such as mitosis, ciliogenesis and neurotransmission. Their phosphorylation activity has also linked them to the development of neurodegenerative diseases like Alzheimer's disease, amyotrophic lateral sclerosis or spinocerebellar ataxia type 11. Human tau-tubulin kinase 1 (TTBK1) gene is located on chromosome 6p21.1. TTBK1 is a serine/threonine/tyrosine kinase that is conserved among species and belongs to the casein kinase 1 superfamily. It is specifically expressed in the brain, especially in the cytoplasm of cortical and hippocampal neurons. TTBK2 is ubiquitously expressed in multiple tissues and genetically linked to spinocerebellar ataxia type 11. TTBK2 is ubiquitously expressed in multiple tissues and genetically linked to spinocerebellar ataxia type 11. TTBK1 directly phosphorylates tau protein, especially at Ser422, and also activates cycline-dependent kinase 5 in a unique mechanism.

References

Sato S, et al. (2006) Tau-tubulin kinase 1 (ttbk1), a neuron-specific tau kinase candidate, is involved in tau phosphorylation and aggregation. J Neurochem 98 (5): 1573-1584.Nozal V, et al. (2019) Tau tubulin kinase 1 (ttbk1), a new player in the fight against neurodegenerative diseases. Eur J Med Chem 161 39-47.Ikezu S, et al. (2014) Tau-tubulin kinase. Front Mol Neurosci 7 33.