Rabbit anti-Human NUDT14 Polyclonal Antibody | anti-NUDT14 antibody
NUDT14 Antibody; FITC conjugated
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the Nudix hydrolase family. Nudix hydrolases eliminate potentially toxic nucleotide metabolites from the cell and regulate the concentrations and availability of many different nucleotide substrates, cofactors, and signaling molecules. This enzyme contains a Nudix hydrolase domain and is a UDPG pyrophosphatase that hydrolyzes UDPG to produce glucose 1-phosphate and UMP. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]
Uniprot Description
NUDT14: Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and ADP-ribose to ribose 5-phosphate and AMP. The physiological substrate is probably UDP-glucose. Poor activity on other substrates such as ADP-glucose, CDP-glucose, GDP-glucose and GDP- mannose. Belongs to the Nudix hydrolase family.
Protein type: EC 3.6.1.45; Hydrolase
Chromosomal Location of Human Ortholog: 14q32.33
Cellular Component: cytoplasm
Molecular Function: ADP-ribose diphosphatase activity; metal ion binding; protein binding; UDP-sugar diphosphatase activity
Biological Process: metabolic process