Western Blot (WB)
(WB Suggested Anti-Nppc AntibodyTitration: 1.0 ug/mlPositive Control: Mouse Brain)
Rabbit Nppc Polyclonal Antibody | anti-NPPC antibody
Nppc Antibody - C-terminal region
Western Blot (WB)
(WB Suggested Anti-Nppc AntibodyTitration: 1.0 ug/mlPositive Control: Mouse Brain)
Western Blot (WB)
(WB Suggested Anti-Nppc AntibodyTitration: 1.0 ug/mlPositive Control: Mouse Brain)
Target Description: This gene encodes a member of the natriuretic peptide family. Natriuretic peptides are involved in the control of blood pressure, extracellular fluid volume and electrolyte homeostasis. The encoded protein also plays a role in sensory neuron bifurcation, and is a critical regulator of endochondral bone growth. The encoded protein is a ligand for the natriuretic peptide receptor B, and is synthesized as a preprohormone which is cleaved to produce a mature peptide. Mutations in this gene are associated with dwarfism resulting from impaired endochondral ossification.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the natriuretic peptide family. Natriuretic peptides are involved in the control of blood pressure, extracellular fluid volume and electrolyte homeostasis. The encoded protein also plays a role in sensory neuron bifurcation, and is a critical regulator of endochondral bone growth. The encoded protein is a ligand for the natriuretic peptide receptor B, and is synthesized as a preprohormone which is cleaved to produce a mature peptide. Mutations in this gene are associated with dwarfism resulting from impaired endochondral ossification. [provided by RefSeq, Apr 2011]
Uniprot Description
NPPC: Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation. May also be vasoactive and natriuretic. Specifically binds and stimulates the cGMP production of the NPR2 receptor. Binds the clearance receptor NPR3. Belongs to the natriuretic peptide family.
Protein type: Secreted; Secreted, signal peptide; Hormone
Cellular Component: extracellular region; extracellular space; secretory granule
Molecular Function: hormone activity; neuropeptide hormone activity; peptide hormone receptor binding; protein homodimerization activity; receptor binding
Biological Process: cGMP biosynthetic process; negative regulation of cell proliferation; negative regulation of DNA metabolic process; negative regulation of meiotic cell cycle; organ development; ossification; positive regulation of cGMP biosynthetic process; positive regulation of osteoblast differentiation; positive regulation of vasodilation; post-embryonic development; receptor guanylyl cyclase signaling pathway; regulation of blood vessel size; regulation of cAMP metabolic process; regulation of cGMP metabolic process; regulation of multicellular organism growth
Research Articles on NPPC
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Product Notes
The NPPC nppc (Catalog #AAA3213485) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Nppc Antibody - C-terminal region reacts with Cow, Dog, Goat, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Sheep and may cross-react with other species as described in the data sheet. AAA Biotech's Nppc can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the NPPC nppc for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Synthetic peptide located within the following region: LLRDLRVDTK SRAAWARLLH EHPNARKYKG GNKKGLSKGC FGLKLDRIGS. It is sometimes possible for the material contained within the vial of "Nppc, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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