Western Blot (WB)
(WB Suggested Anti-LPP Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: COLO205 cell lysateLPP is supported by BioGPS gene expression data to be expressed in COLO205)
Rabbit LPP Polyclonal Antibody | anti-LPP antibody
LPP antibody - N-terminal region
Western Blot (WB)
(WB Suggested Anti-LPP Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: COLO205 cell lysateLPP is supported by BioGPS gene expression data to be expressed in COLO205)
Western Blot (WB)
(WB Suggested Anti-LPP Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: COLO205 cell lysateLPP is supported by BioGPS gene expression data to be expressed in COLO205)
Target Description: LPP may play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. LPP may be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. LPP is also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of a subfamily of LIM domain proteins that are characterized by an N-terminal proline-rich region and three C-terminal LIM domains. The encoded protein localizes to the cell periphery in focal adhesions and may be involved in cell-cell adhesion and cell motility. This protein also shuttles through the nucleus and may function as a transcriptional co-activator. This gene is located at the junction of certain disease-related chromosomal translocations, which result in the expression of chimeric proteins that may promote tumor growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Uniprot Description
LPP: a LIM domain-containing that may function in focal adhesion and nuclear targeting.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis; Adaptor/scaffold
Chromosomal Location of Human Ortholog: 3q28
Cellular Component: focal adhesion; cytoplasm; plasma membrane; nucleus
Molecular Function: protein binding; zinc ion binding
Biological Process: cell adhesion
Disease: Leukemia, Acute Myeloid
Research Articles on LPP
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Product Notes
The LPP lpp (Catalog #AAA3211421) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The LPP antibody - N-terminal region reacts with Cow, Dog, Horse, Human, Mouse, Rabbit and may cross-react with other species as described in the data sheet. AAA Biotech's LPP can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the LPP lpp for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Synthetic peptide located within the following region: GKTLEERRSS LDAEIDSLTS ILADLECSSP YKPRPPQSST GSTASPPVST. It is sometimes possible for the material contained within the vial of "LPP, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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