Rabbit LPP Polyclonal Antibody | anti-LPP antibody

LPP Antibody (N-Term)

Cat. Num. AAA9215946

• Reactivity: Human, Mouse; Predicted: Mouse, Rat
• Applications: Western Blot
• Synonyms: LPP; Polyclonal Antibody; LPP Antibody (N-Term); Purified Rabbit Polyclonal Antibody (Pab); Lipoma-preferred partner; LIM domain-containing preferred translocation partner in lipoma; anti-LPP antibody

• Host: Rabbit
• Reactivity: Human, Mouse; Predicted: Mouse, Rat
• Clonality: Polyclonal
• Isotype: Ig
• Specificity: This LPP antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 32-66 amino acids from the human LPP.
• Form/Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
• Sequence Length: 612

• Applicable Applications for anti-LPP antibody: Western Blot (WB)
• Application Notes: WB ~~ 1:2000
• Antigen Source: Human
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Western Blot (WB)

(All lanes : Anti-LPP Antibody (N-Term) at 1:2000 dilutionLane 1: C2C12 whole cell lysateLane 2: Caco2 whole cell lysateLane 3: Caki-1 whole cell lysateLane 4: Hela whole cell lysateLane 5: HepG2 whole cell lysateLane 6: MDA-MB-468 whole cell lysateLane 7: MCF-7 whole cell lysateLysates/proteins at 20 ug per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution.Predicted band size : 66 kDaBlocking/Dilution buffer: 5% NFDM/TBST.)

Related Product Information for anti-LPP antibody

May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. May be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. Also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus.

Product Categories/Family for anti-LPP antibody

Signal Transduction

References

Petit M.M.R.,et al.Genomics 36:118-129(1996). Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases. Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. Lemke I.,et al.Cytogenet. Cell Genet. 95:153-156(2001). Petit M.M.,et al.Cancer Genet. Cytogenet. 106:18-23(1998).

NCBI and Uniprot Product Information

• NCBI GI #: 264681524
• NCBI GeneID: 4026
• NCBI Accession #: NP_001161143.1
• NCBI GenBank Nucleotide #: NM_001167671.2
• UniProt Accession #: Q93052; Q8NFX5; A1L4L6; D3DNV6
• Molecular Weight: 65746
• NCBI Official Full Name: lipoma-preferred partner isoform a
• NCBI Official Synonym Full Names: LIM domain containing preferred translocation partner in lipoma
• NCBI Official Symbol: LPP
• NCBI Protein Information: lipoma-preferred partner
• UniProt Protein Name: Lipoma-preferred partner
• Protein Family: LPP20 lipoprotein
• UniProt Gene Name: LPP
• UniProt Entry Name: LPP_HUMAN

NCBI Description

This gene encodes a member of a subfamily of LIM domain proteins that are characterized by an N-terminal proline-rich region and three C-terminal LIM domains. The encoded protein localizes to the cell periphery in focal adhesions and may be involved in cell-cell adhesion and cell motility. This protein also shuttles through the nucleus and may function as a transcriptional co-activator. This gene is located at the junction of certain disease-related chromosomal translocations, which result in the expression of chimeric proteins that may promote tumor growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Uniprot Description

LPP: a LIM domain-containing that may function in focal adhesion and nuclear targeting.

Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis; Cytoskeletal

Chromosomal Location of Human Ortholog: 3q28

Cellular Component: focal adhesion; cytoplasm; plasma membrane; nucleus

Molecular Function: protein binding; zinc ion binding

Biological Process: cell adhesion

Disease: Leukemia, Acute Myeloid