Rabbit LPP Polyclonal Antibody | anti-LPP antibody

anti-LPP antibody

Cat. Num. AAA7612047

• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry, Immunofluorescence
• Purity: >=95% as determined by SDS-PAGE. Immunogen affinity purified
• Synonyms: LPP; Polyclonal Antibody; anti-LPP antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE. Immunogen affinity purified
• Form/Format: Liquid. PBS with 0.02% sodium azide and 50% glycerol pH7.3

• Applicable Applications for anti-LPP antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
• Application Notes: WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200
• Immunogen: LIM domain containing preferred translocation partner in lipoma
• Preparation and Storage: Store at -20 degree C for 12 months. Avoid repeated freeze/thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded rat kidney tissue slide using MBS7612047(LPP antibody) at dilution of 1:100)

Western Blot (WB)

(Various lysates were subjected to SDS PAGE followed by western blot with MBS7612047(LPP antibody) at dilution of 1:1000)

Related Product Information for anti-LPP antibody

May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. May be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. Also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus.

NCBI and Uniprot Product Information

• NCBI GI #: 74751663
• NCBI GeneID: 4026
• UniProt Accession #: Q93052; Q8NFX5; A1L4L6; D3DNV6
• Molecular Weight: 65,746 Da
• NCBI Official Full Name: Lipoma-preferred partner
• NCBI Official Synonym Full Names: LIM domain containing preferred translocation partner in lipoma
• NCBI Official Symbol: LPP
• NCBI Protein Information: lipoma-preferred partner; LIM protein
• UniProt Protein Name: Lipoma-preferred partner
• Protein Family: LPP20 lipoprotein
• UniProt Gene Name: LPP
• UniProt Entry Name: LPP_HUMAN

NCBI Description

This gene encodes a member of a subfamily of LIM domain proteins that are characterized by an N-terminal proline-rich region and three C-terminal LIM domains. The encoded protein localizes to the cell periphery in focal adhesions and may be involved in cell-cell adhesion and cell motility. This protein also shuttles through the nucleus and may function as a transcriptional co-activator. This gene is located at the junction of certain disease-related chromosomal translocations, which result in the expression of chimeric proteins that may promote tumor growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Uniprot Description

LPP: a LIM domain-containing that may function in focal adhesion and nuclear targeting.

Protein type: Cytoskeletal; Motility/polarity/chemotaxis; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 3q28

Cellular Component: focal adhesion; cytoplasm; plasma membrane; nucleus

Molecular Function: protein binding; zinc ion binding

Biological Process: cell adhesion

Disease: Leukemia, Acute Myeloid