Testing Data
Rabbit anti-Rat K2P6.1 Polyclonal Antibody | anti-K2P6.1 antibody
Anti-K2P6.1 (TWIK-2) Antibody
Gene Names
KCNK6; TOSS; KCNK8; TWIK2; K2p6.1; TWIK-2
Reactivity
Rat
Applications
Western Blot
Purity
Affinity Purified On Immobilized Antigen
Synonyms
K2P6.1; Polyclonal Antibody; Anti-K2P6.1 (TWIK-2) Antibody; K 2P6-1 (TWIK-2); anti-K2P6.1 antibody
Host
Rabbit
Reactivity
Rat
Clonality
Polyclonal
Specificity
Rat-13/17 residues identical.
Purity/Purification
Affinity Purified On Immobilized Antigen
Form/Format
Liquid; PBS, pH 7.4 with 0.05% sodium azide.
Concentration
1ug/ul (varies by lot)
Sequence Length
313
Applicable Applications for anti-K2P6.1 antibody
Western Blot (WB)
Application Notes
WB: Rat brain membranes (1:200)
Immunogen
Peptide (C)ESHQQLSASSHTDYASIPR, corresponding to residues 295-313 of human K2P6.1 (TWIK-2) (Accession Q9Y257).
Preparation and Storage
This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use.
For extended storage, aliquot contents and freeze at-20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
For extended storage, aliquot contents and freeze at-20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Testing Data
Testing Data
Related Product Information for anti-K2P6.1 antibody
Kcnk6, TOSS K2P6.1 (also named Tandem of P domain of Weak Inward rectifier K+ channel 2, TWIK-2 or KCNK6) is a member of the 2-pore (2P) domain K+ channel family that includes at least 16 members. These channels show little time or voltage dependence and are considered to be-leak-or-background-K+ channels, thereby generating background currents which help set the membrane resting potential and cell excitation. The K2P channels have a signature topology that includes four transmembrane domains and two pore domains with intracellular N-and C termini. The functional channel is believed to be a dimer. K2P channels are regulated by diverse physical and chemical stimuli including temperature, changes in intracellular pH, mechanical stretch, inhalation anesthetics, etc. The channels can then be subclassified based in their specific activators. K2P6.1 displays low single channel conductance of about 5pS and is partially activated by arachidonic acid and blocked by volatile anesthetics. K2P6.1 expression is widespread, especially in the rat were it is expressed in brain, heart, kidney and liver. In humans K2P6.1 expression is more restricted with expression in aorta, stomach, placenta and spleen while in mouse, K2P6.1 expression has been detected only in liver.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Official Full Name
K2P6.1 potassium channel
NCBI Official Synonym Full Names
potassium two pore domain channel subfamily K member 6
NCBI Official Symbol
KCNK6
NCBI Official Synonym Symbols
TOSS; KCNK8; TWIK2; K2p6.1; TWIK-2
NCBI Protein Information
potassium channel subfamily K member 6
NCBI Description
This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. This channel protein, considered an open rectifier, is widely expressed. It is stimulated by arachidonic acid, and inhibited by internal acidification and volatile anaesthetics. [provided by RefSeq, Jul 2008]
Research Articles on K2P6.1
Similar Products
Product Notes
The K2P6.1 (Catalog #AAA4159246) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-K2P6.1 (TWIK-2) Antibody reacts with Rat and may cross-react with other species as described in the data sheet. AAA Biotech's K2P6.1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: Rat brain membranes (1:200). Researchers should empirically determine the suitability of the K2P6.1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "K2P6.1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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