Rabbit anti-Rat K2P5.1 Polyclonal Antibody | anti-K2P5.1 antibody

Anti-K2P5.1 (TASK-2) Antibody

Cat. Num. AAA4159245

• Gene Names: KCNK5; TASK2; K2p5.1; KCNK5b; TASK-2
• Reactivity: Rat
• Applications: Western Blot, Immunohistochemistry
• Purity: Affinity Purified On Immobilized Antigen.
• Synonyms: K2P5.1; Polyclonal Antibody; Anti-K2P5.1 (TASK-2) Antibody; K 2P5-1 (TASK-2); anti-K2P5.1 antibody

• Host: Rabbit
• Reactivity: Rat
• Clonality: Polyclonal
• Specificity: Mouse-14/17 residues identical.
• Purity/Purification: Affinity Purified On Immobilized Antigen.
• Form/Format: Liquid; PBS, pH 7.4 with 0.05% sodium azide.
• Concentration: 1ug/ul (varies by lot)
• Sequence Length: 499

• Applicable Applications for anti-K2P5.1 antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: WB: Rat kidney membranes (1:200); IHC: Rat kidney sections.
• Immunogen: Peptide (C)YEQLMNEYNKANSPKGT, amino acid residues 483-499 of human K2P5.1 (Accession number O95279).
• Preparation and Storage: This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use.; For extended storage, aliquot contents and freeze at-20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

Testing Data

Testing Data

Related Product Information for anti-K2P5.1 antibody

TWIK-Related Acid Sensitive K+ Channel 2, Kcnk5 K2P5.1 (also named TWIK-Related Acid Sensitive K+ channel 2, TASK-2 or KCNK5) is a member of the 2-pore (2P) domain K+ channels family that includes at least 16 members. These channels show little time or voltage dependence and are considered to be-leak-or-background-K+ channels, thereby generating background currents which help set the membrane resting potential and cell excitation. The K2P channels have a signature topology that includes four transmembrane domains and two pore domains with intracellular N-and C termini. The functional channel is believed to be a dimer. K2P channels are regulated by diverse physical and chemical stimuli including temperature, changes in intracellular pH, mechanical stretch, inhalation anesthetics, etc. The channels can then be subclassified based in their specific activators. As indicated by its name, K2P5.1 is sensitive to variations in external pH. K2P5.1 current is maximal at pH 8.8 but it is only 10% at pH 6.5. The channel is expressed in several epithelial tissues including pancreas, lung, small intestine and specially kidney. In the kidney K2P5.1 has an important function in NaHCO3 absorption in the proximal tubule as knockout mice for K2P5.1 display metabolic acidosis and hypotension.

NCBI and Uniprot Product Information

• NCBI GI #: 198385509
• NCBI GeneID: 8645
• NCBI Official Full Name: K2P5.1 potassium channel
• NCBI Official Synonym Full Names: potassium two pore domain channel subfamily K member 5
• NCBI Official Symbol: KCNK5
• NCBI Official Synonym Symbols: TASK2; K2p5.1; KCNK5b; TASK-2
• NCBI Protein Information: potassium channel subfamily K member 5

NCBI Description

This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The message for this gene is mainly expressed in the cortical distal tubules and collecting ducts of the kidney. The protein is highly sensitive to external pH and this, in combination with its expression pattern, suggests it may play an important role in renal potassium transport. [provided by RefSeq, Jul 2008]