Rabbit GluR1,2 delta Polyclonal Antibody

GluR1,2 delta (Glutamate Receptor)

Cat. Num. AAA620137

• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: GluR1; 2 delta; Polyclonal Antibody; 2 delta (Glutamate Receptor); Anti -GluR1; anti-GluR1; 2 delta antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes the C-Terminus of Glutamate receptor delta 1 and delta 2. Species Crossreactivity
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in 0.1M Tris-Glycine, pH7.4, 150mM sodium chloride, 0.05% sodium azide.

• Applicable Applications for anti-GluR1,2 delta antibody: Western Blot (WB)
• Application Notes: Suitable for use in Western Blot.; Dilution: Western Blot: 1:5000
• Immunogen: Synthetic linear peptide to the C-Terminus, conjugated to BSA. Cellular Localization: Cell membrane; Multi-pass membrane protein.
• Positive Control: Rat cerebellum tissue lysate and human cerebellum tissue lysate
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Western Blot (WB)

(Western Blot Analysis: Rat Cerebellum lysate was resolved by electrophoresis, transferred to PVDF and probed with anti-Glutamate Receptor delta1 and 2 (1:5,000 dilution). Proteins were visualized using a donkey anti-rabbit secondary antibody conjugated to HRP and a chemiluminescence detection system. Arrow indicates Glutamate Receptor Delta 1 and 2 (114kD).)

Chemiluminescence

(Human Cerebellum lysate was resolved by electrophoresis, transferred to PVDF and probed with anti-Glutamate Receptor Delta 1/2 . Proteins were visualized using a donkey anti-rabbit secondary antibody conjugated to HRP and a chemiluminescence detection system. Arrow indicates Glutamate Receptor Delta 1/2 (114kD))

Related Product Information for anti-GluR1,2 delta antibody

The majority of rapid excitatory transmission in the nervous system is mediated by glutamate-activated ion channels. Ionotropic glutamate receptors have been subdivided pharmacologically into AMPA (cx-amino-3-hydroxy-5methyl-Cisoxazole propionic acid), KA (kainate), and NMDA subtypes (Monaghan et al., 1989). These receptors have been implicated in a number of physiological and pathological processes. During development glutamate receptors are involved in neuronal differentiation, migration, and activity-dependent synapse formation (Balazs et al., 1989; Brewer, 1989; Komoru and Rakic, 1993). In mature neurons, long-term potentiation and long-term depression require ionotropic glutamate receptors. Glutamate-gated ion channels also play a central role in mediating the excitotoxic effects of glutamate (Olney, 1990). Pathophysiological processes thought to involve glutamate excitotoxicity and neurodegeneration include epilepsy stroke, Parkinson's disease, Alzheimer's disease, Huntington's disease, and amyotrophic lateral sclerosis.

Product Categories/Family for anti-GluR1,2 delta antibody

Antibodies; Abs to Receptors