Immunohistochemistry (IHC)
(Immunochemical staining of human DNAAF2 in human testis with rabbit polyclonal antibody at 1:300 dilution, formalin-fixed paraffin embedded sections.)
Rabbit anti-Human DNAAF2 Polyclonal Antibody | anti-DNAAF2 antibody
Anti-DNAAF2 Antibody, Rabbit Polyclonal
Gene Names
DNAAF2; KTU; PF13; CILD10; C14orf104
Reactivity
Human
Applications
Immunohistochemistry
Purity
Protein A & Antigen Affinity
Synonyms
DNAAF2; Polyclonal Antibody; Anti-DNAAF2 Antibody; Rabbit Polyclonal; DNAAF2 Antibody; Rabbit PAb; Antigen Affinity Purified; Anti-C14orf104 Antibody; Anti-KTU Antibody; Anti-PF13 Antibody; anti-DNAAF2 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
Human DNAAF2
Purity/Purification
Protein A & Antigen Affinity
Form/Format
Liquid; PBS, pH7.0 with 0.03% Proclin300
Applicable Applications for anti-DNAAF2 antibody
Immunohistochemistry-Paraffin (IHC-P)
Application Notes
IHC-P: 1:200-1:1000
Immunogen
A synthetic peptide corresponding to the N-terminus of the Human DNAAF2
Conjugation
Unconjugated
Preparation
Produced in rabbits immunized with a synthetic peptide corresponding to the N-terminus of the Human DNAAF2, and purified by antigen affinity chromatography.
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Avoid repeated freeze-thaw cycles.
Immunohistochemistry (IHC)
(Immunochemical staining of human DNAAF2 in human testis with rabbit polyclonal antibody at 1:300 dilution, formalin-fixed paraffin embedded sections.)
Immunohistochemistry (IHC)
(Immunochemical staining of human DNAAF2 in human testis with rabbit polyclonal antibody at 1:300 dilution, formalin-fixed paraffin embedded sections.)
Related Product Information for anti-DNAAF2 antibody
The dynein axonemal assembly factor (DNAAF) protein family is involved in preassembly and stability of dynein arms before they are transported into the cilia. In humans, mutations in DNAAF genes lead to several diseases related to cilia defects such as primary ciliary dyskinesia (PCD; OMIM: 612518). DNAAF3 (PF22) acts at a similar stage as other preassembly proteins, for example, DNAAF2 (also known as PF13 or KTU) and DNAAF1 (also known as ODA7 or LRRC50), in the dynein preassembly pathway. Knockdown of dnaaf3 in zebrafish likewise disrupts dynein arm assembly and ciliary motility, causing primary ciliary dyskinesia phenotypes that include hydrocephalus and laterality malformations. Hypomorphic mutations of human DNAAF2 can result in ciliary dyskinesia and Dnaaf2 is an essential component of cilia function in vivo.
References
Tarkar A, et al. (2013) Dyx1c1 is required for axonemal dynein assembly and ciliary motility. Nat Genet 45 (9): 995-1003.Mitchison HM, et al. (2012) Mutations in axonemal dynein assembly factor dnaaf3 cause primary ciliary dyskinesia. Nat Genet 44 (4): 381-389, s381-382.Cheong A, et al. (2019) A null allele of dnaaf2 displays embryonic lethality and mimics human ciliary dyskinesia. Hum Mol Genet 28 (16): 2775-2784.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
91,114 Da
NCBI Official Full Name
protein kintoun isoform 2
NCBI Official Synonym Full Names
dynein, axonemal, assembly factor 2
NCBI Official Symbol
DNAAF2
NCBI Official Synonym Symbols
KTU; PF13; CILD10; C14orf104
NCBI Protein Information
protein kintoun; dynein assembly factor 2, axonemal
UniProt Protein Name
Protein kintoun
UniProt Gene Name
DNAAF2
UniProt Synonym Gene Names
C14orf104; KTU
UniProt Entry Name
KTU_HUMAN
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Product Notes
The DNAAF2 dnaaf2 (Catalog #AAA8102445) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-DNAAF2 Antibody, Rabbit Polyclonal reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's DNAAF2 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry-Paraffin (IHC-P). IHC-P: 1:200-1:1000. Researchers should empirically determine the suitability of the DNAAF2 dnaaf2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "DNAAF2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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