Western Blot (WB)
(SEMA6A Antibody (N-term) western blot analysis in A2058 cell line lysates (15ug/lane).This demonstrates the SEMA6A antibody detected the SEMA6A protein (arrow).)
Rabbit SEMA6A Polyclonal Antibody | anti-SEMA6A antibody
SEMA6A Antibody (N-term)
Gene Names
SEMA6A; VIA; SEMA; HT018; SEMAQ; SEMA6A1
Reactivity
Human (Predicted Reactivity: Mouse)
Applications
Western Blot, ELISA
Purity
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Synonyms
SEMA6A; Polyclonal Antibody; SEMA6A Antibody (N-term); Semaphorin-6A; Semaphorin VIA; Sema VIA; Semaphorin-6A-1; SEMA6A-1; KIAA1368; SEMAQ; anti-SEMA6A antibody
Host
Rabbit
Reactivity
Human (Predicted Reactivity: Mouse)
Clonality
Polyclonal
Isotype
Rabbit Ig
Specificity
This SEMA6A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 29-57 amino acids from the N-terminal region of human SEMA6A.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.5 (varies by lot)
Sequence Positions
29-57
Sequence Length
1,047
Applicable Applications for anti-SEMA6A antibody
Western Blot (WB), ELISA (EIA)
Application Notes
WB~~1:1000
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Western Blot (WB)
(SEMA6A Antibody (N-term) western blot analysis in A2058 cell line lysates (15ug/lane).This demonstrates the SEMA6A antibody detected the SEMA6A protein (arrow).)
Western Blot (WB)
(SEMA6A Antibody (N-term) western blot analysis in A2058 cell line lysates (15ug/lane).This demonstrates the SEMA6A antibody detected the SEMA6A protein (arrow).)
Related Product Information for anti-SEMA6A antibody
SEMA6A belongs to a subfamily characterized by an extracellular semaphorin domain, a transmembrane domain, and a long cytoplasmic tail. Members of this class can repel sympathetic and dorsal root ganglion axons in vitro, consistent with a traditional role as guidance signals. However, the length of the cytoplasmic tail, which includes an EVL-binding site in SEMA6A and an Src-binding site in SEMA6B, suggests that these semaphorins may also function as receptors. SEMA6A is expressed in developing neural tissue and is required for proper development of the thalamocortical projection. SEMA6A directly links the Ena/VASP and the semaphorin protein families since the SEMA6A protein is capable of selective binding to the protein EVL (Ena/VASP-like protein).
Product Categories/Family for anti-SEMA6A antibody
References
Johnson, M.P., et al. Hum. Genet. 126(5):655-666(2009)
Landers, J.E., et al. Proc. Natl. Acad. Sci. U.S.A. 106(22):9004-9009(2009)
Prislei, S., et al. Mol. Cancer Ther. 7(1):233-241(2008)
Landers, J.E., et al. Proc. Natl. Acad. Sci. U.S.A. 106(22):9004-9009(2009)
Prislei, S., et al. Mol. Cancer Ther. 7(1):233-241(2008)
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
114395
NCBI Official Full Name
semaphorin-6A isoform 2
NCBI Official Synonym Full Names
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
NCBI Official Symbol
SEMA6A
NCBI Official Synonym Symbols
VIA; SEMA; HT018; SEMAQ; SEMA6A1
NCBI Protein Information
semaphorin-6A
UniProt Protein Name
Semaphorin-6A
Protein Family
UniProt Gene Name
SEMA6A
UniProt Synonym Gene Names
KIAA1368; SEMAQ; Sema VIA; SEMA6A-1
UniProt Entry Name
SEM6A_HUMAN
NCBI Description
The transmembrane semaphorin SEMA6A is expressed in developing neural tissue and is required for proper development of the thalamocortical projection (Leighton et al., 2001 [PubMed 11242070]).[supplied by OMIM, Feb 2011]
Uniprot Description
SEMA6A: a single-pass type I membrane protein of the semaphorin family that can act as repulsive axon guidance cues. May play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation. Active as a homodimer or oligomer. Interacts with EVL. Two isoforms of the human protein are produced by alternative splicing.
Protein type: Cell adhesion; Membrane protein, integral
Chromosomal Location of Human Ortholog: 5q23.1
Cellular Component: axon; plasma membrane; integral to membrane
Molecular Function: protein binding; receptor activity
Biological Process: nervous system development; axon guidance; organ morphogenesis; cell surface receptor linked signal transduction; apoptosis; cytoskeleton organization and biogenesis
Research Articles on SEMA6A
Similar Products
Product Notes
The SEMA6A sema6a (Catalog #AAA9208631) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 29-57. The SEMA6A Antibody (N-term) reacts with Human (Predicted Reactivity: Mouse) and may cross-react with other species as described in the data sheet. AAA Biotech's SEMA6A can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the SEMA6A sema6a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SEMA6A, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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