Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Rabbit anti-Rat Disrupted In Schizophrenia 1 (DISC1) Polyclonal Antibody | anti-DISC1 antibody
Polyclonal Antibody to Disrupted In Schizophrenia 1 (DISC1)
Reactivity
Rat
Applications
Immunocytochemistry, Immunohistochemistry, ELISA, Western Blot
Purity
Affinity Chromatography
Synonyms
Disrupted In Schizophrenia 1 (DISC1); Polyclonal Antibody; Polyclonal Antibody to Disrupted In Schizophrenia 1 (DISC1); anti-DISC1 antibody
Host
Rabbit
Reactivity
Rat
Clonality
Polyclonal
Specificity
The antibody is a rabbit polyclonal antibody raised against DISC1. It has been selected for its ability to recognize DISC1 in immunohistochemical staining andwestern blotting.
Purity/Purification
Affinity Chromatography
Form/Format
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
Concentration
500ug/mL (varies by lot)
Sequence
Antigen: The target protein is fused with two N-terminal Tags, His-tag and T7-tag and its sequence is listed below.
MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- EFLSSDSSKS LASSLDVAWS KGSRGLKTVR PLVSPASNGP VDIPSLPGFQ DTFTSNFSFI RLSLGAAGER GEAEGCLPSR EAEPLHQSPQ EMAAEGSGSD RPHGEPRHLW TFSLHAAPGL VDLAQGTRSN RQPECGMVSS SDAGFSSQDA SPAGGRSDQD GGWADAHGWH ALLREWEPML
MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- EFLSSDSSKS LASSLDVAWS KGSRGLKTVR PLVSPASNGP VDIPSLPGFQ DTFTSNFSFI RLSLGAAGER GEAEGCLPSR EAEPLHQSPQ EMAAEGSGSD RPHGEPRHLW TFSLHAAPGL VDLAQGTRSN RQPECGMVSS SDAGFSSQDA SPAGGRSDQD GGWADAHGWH ALLREWEPML
Sequence Length
678
Applicable Applications for anti-DISC1 antibody
Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)
Application Notes
Western blotting: 1:100-400
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200
Immunogen
Recombinant DISC1 (Glu151~Gln340) expressed in E.coli.
Cross Reactivity
Rat
Conjugated Antibody
The APC conjugated antibody version of this item is also available as catalog #MBS2064401
Preparation and Storage
Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Immunohistochemistry (IHC)
(DAB staining on fromalin fixed paraffin-embedded Liver tissue))
Immunohistochemistry (IHC)
(DAB staining on fromalin fixed paraffin-embedded Liver tissue))
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
90,102 Da
NCBI Official Full Name
disrupted in schizophrenia 1 homolog
NCBI Official Synonym Full Names
disrupted in schizophrenia 1
NCBI Official Symbol
Disc1
NCBI Protein Information
disrupted in schizophrenia 1 homolog
UniProt Protein Name
Disrupted in schizophrenia 1 homolog
Protein Family
UniProt Gene Name
Disc1
NCBI Description
interacts with a variety of cytoskeletal proteins; truncated mutant form is associated with Schizophrenia [RGD, Feb 2006]
Uniprot Description
Involved in the regulation of multiple aspects of embryonic and adult neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation. Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A. Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. Plays a role, together with PCNT, in the microtubule network formation.
Research Articles on DISC1
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Product Notes
The DISC1 disc1 (Catalog #AAA2014687) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to Disrupted In Schizophrenia 1 (DISC1) reacts with Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Disrupted In Schizophrenia 1 (DISC1) can be used in a range of immunoassay formats including, but not limited to, Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB). Western blotting: 1:100-400 Immunocytochemistry in formalin fixed cells: 1:100-500 Immunohistochemistry in formalin fixed frozen section: 1:100-500 Immunohistochemistry in paraffin section: 1:50-200 Enzyme-linked Immunosorbent Assay: 1:100-200. Researchers should empirically determine the suitability of the DISC1 disc1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Antigen: The target protein is fused with two N-terminal Tags, His-tag and T7-tag and its sequence is listed below. MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- EFLSSDSSKS LASSLDVAWS KGSRGLKTVR PLVSPASNGP VDIPSLPGFQ DTFTSNFSFI RLSLGAAGER GEAEGCLPSR EAEPLHQSPQ EMAAEGSGSD RPHGEPRHLW TFSLHAAPGL VDLAQGTRSN RQPECGMVSS SDAGFSSQDA SPAGGRSDQD GGWADAHGWH ALLREWEPML. It is sometimes possible for the material contained within the vial of "Disrupted In Schizophrenia 1 (DISC1), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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