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Disrupted In Schizophrenia 1 (DISC1) Recombinant Protein | DISC1 recombinant protein
Recombinant Disrupted In Schizophrenia 1 (DISC1)
MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- EFLSSDSSKS LASSLDVAWS KGSRGLKTVR PLVSPASNGP VDIPSLPGFQ DTFTSNFSFI RLSLGAAGER GEAEGCLPSR EAEPLHQSPQ EMAAEGSGSD RPHGEPRHLW TFSLHAAPGL VDLAQGTRSN RQPECGMVSS SDAGFSSQDA SPAGGRSDQD GGWADAHGWH ALLREWEPMLQDYLLSNRRQ
Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.
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NCBI and Uniprot Product Information
NCBI Description
interacts with a variety of cytoskeletal proteins; truncated mutant form is associated with Schizophrenia [RGD, Feb 2006]
Uniprot Description
Function: Involved in the regulation of multiple aspects of embryonic and adult neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation. Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A. Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. Plays a role, together with PCNT, in the microtubule network formation. Ref.4
Subunit structure: Interacts with CCDC88A (via C-terminus); the interaction is direct. Interacts with GSK3B. Interacts (via C-terminal) with PCNT. Interacts with tubulin alpha, ACTN2, ANKHD1, ATF4, ATF5, CEP63, EIF3S3, MAP1A, NDEL1, PAFAH1B1, RANBP9, SPTBN4, SYNE1 and TRAF3IP1. Interaction with microtubules may be mediated in part by TRAF3IP1. Interacts with CHCHD6
By similarity. Interacts with NDEL1. Ref.4
Subcellular location: Cytoplasm › cytoskeleton › microtubule organizing center › centrosome. Cytoplasm. Cell junction › synapse › postsynaptic cell membrane › postsynaptic density
By similarity. Note: Colocalizes with PCNT at the centrosome
By similarity. Localizes to punctate cytoplasmic foci which may overlap in part with mitochondria. Colocalizes with NDEL1 in the perinuclear region and the centrosome. Ref.1 Ref.4
Tissue specificity: Expressed in brain, heart, kidney, liver and thymus. Within the brain expression is high in the cerebral cortex, hippocampus and olfactory bulb and is also seen at lower levels in the cerebellum. Ref.1
Developmental stage: Expressed at high levels at E20.5. Expressed at lower levels at P2 and P6. Ref.1
Induction: Up-regulated during neurite outgrowth upon differentiation with NGF. Ref.4
Research Articles on DISC1
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Product Notes
The DISC1 disc1 (Catalog #AAA2018723) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Disrupted In Schizophrenia 1 (DISC1) can be used in a range of immunoassay formats including, but not limited to, SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP). Researchers should empirically determine the suitability of the DISC1 disc1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: The target protein is fused with two N-terminal Tags, His-tag and T7-tag, its sequence is listed below. MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- EFLSSDSSKS LASSLDVAWS KGSRGLKTVR PLVSPASNGP VDIPSLPGFQ DTFTSNFSFI RLSLGAAGER GEAEGCLPSR EAEPLHQSPQ EMAAEGSGSD RPHGEPRHLW TFSLHAAPGL VDLAQGTRSN RQPECGMVSS SDAGFSSQDA SPAGGRSDQD GGWADAHGWH ALLREWEPML QDYLLSNRRQ. It is sometimes possible for the material contained within the vial of "Disrupted In Schizophrenia 1 (DISC1), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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