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Immunohistochemistry (IHC) (The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using (CCAR2 Antibody) at dilution 1/20.)

Rabbit anti-Human, Mouse CCAR2 Polyclonal Antibody | anti-CCAR2 antibody

CCAR2 Antibody

Gene Names
CCAR2; DBC1; DBC-1; NET35; p30DBC; p30 DBC; KIAA1967
Reactivity
Human, Mouse
Applications
Immunohistochemistry
Purity
Antigen affinity purification
Synonyms
CCAR2; Polyclonal Antibody; CCAR2 Antibody; DBC1; DBC-1; NET35; p30DBC; p30 DBC; KIAA1967; anti-CCAR2 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Purity/Purification
Antigen affinity purification
Form/Format
pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Concentration
0.6mg/mL (varies by lot)
Sequence Length
923
Applicable Applications for anti-CCAR2 antibody
Immunohistochemistry (IHC)
Application Notes
IHC: 1:50-1:100
Immunogen
Synthetic peptide of human CCAR2
Conjugation
Unconjugated
Preparation and Storage
Store at -20 degree C for 1 year.

Immunohistochemistry (IHC)

(The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using (CCAR2 Antibody) at dilution 1/20.)

Immunohistochemistry (IHC) (The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using (CCAR2 Antibody) at dilution 1/20.)
Related Product Information for anti-CCAR2 antibody
Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis. Inhibits SUV39H1 methyltransferase activity. As part of a histone H3-specific methyltransferase complex may mediate ligand-dependent transcriptional activation by nuclear hormone receptors. Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress. Regulates the circadian expression of the core clock components NR1D1 and ARNTL/BMAL1. Enhances the transcriptional repressor activity of NR1D1 through stabilization of NR1D1 protein levels by preventing its ubiquitination and subsequent degradation (PubMed:18235501, PubMed:18235502, PubMed:19131338, PubMed:19218236, PubMed:22446626, PubMed:23352644, PubMed:23398316). Represses the ligand-dependent transcriptional activation function of ESR2 (PubMed:20074560). Acts as a regulator of PCK1 expression and gluconeogenesis by a mechanism that involves, at least in part, both NR1D1 and SIRT1 (PubMed:24415752). Negatively regulates the deacetylase activity of HDAC3 and can alter its subcellular localization (PubMed:21030595). Positively regulates the beta-catenin pathway (canonical Wnt signaling pathway) and is required for MCC-mediated repression of the beta-catenin pathway (PubMed:24824780). Represses ligand-dependent transcriptional activation function of NR1H2 and NR1H3 and inhibits the interaction of SIRT1 with NR1H3 (PubMed:25661920). Plays an important role in tumor suppression through p53/TP53 regulation; stabilizes p53/TP53 by affecting its interaction with ubiquitin ligase MDM2 (PubMed:25732823). Represses the transcriptional activator activity of BRCA1 (PubMed:20160719). Inhibits SIRT1 in a CHEK2 and PSEM3-dependent manner and inhibits the activity of CHEK2 in vitro (PubMed:25361978).
Product Categories/Family for anti-CCAR2 antibody

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
NCBI Official Full Name
cell cycle and apoptosis regulator protein 2 isoform 1
NCBI Official Synonym Full Names
cell cycle and apoptosis regulator 2
NCBI Official Symbol
CCAR2
NCBI Official Synonym Symbols
DBC1; DBC-1; NET35; p30DBC; p30 DBC; KIAA1967
NCBI Protein Information
cell cycle and apoptosis regulator protein 2
UniProt Protein Name
SOSS complex subunit B2
UniProt Gene Name
NABP1
UniProt Synonym Gene Names
OBFC2A; SSB2; SOSS-B2; hSSB2
UniProt Entry Name
SOSB2_HUMAN

Uniprot Description

OBFC2A: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. Belongs to the SOSS-B family. SOSS-B2 subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; DNA repair, damage; Cell cycle regulation

Chromosomal Location of Human Ortholog: 2q32.3

Cellular Component: nucleoplasm; cytoplasm; nucleus

Molecular Function: RNA binding; single-stranded DNA binding

Biological Process: mitotic cell cycle checkpoint; response to ionizing radiation; DNA repair; response to DNA damage stimulus; double-strand break repair via homologous recombination

Research Articles on CCAR2

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Product Notes

The CCAR2 nabp1 (Catalog #AAA9434800) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CCAR2 Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's CCAR2 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC). IHC: 1:50-1:100. Researchers should empirically determine the suitability of the CCAR2 nabp1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CCAR2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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