Rabbit anti-Human KIAA1967 Polyclonal Antibody | anti-KIAA1967 antibody

KIAA1967 Antibody

Cat. Num. AAA9405126

• Gene Names: CCAR2; DBC1; DBC-1; NET35; p30DBC; p30 DBC; KIAA1967
• Reactivity: Human
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Synonyms: KIAA1967; Polyclonal Antibody; KIAA1967 Antibody; Protein KIAA1967; Deleted in breast cancer gene 1 protein; DBC.1; DBC-1; p30 DBC; anti-KIAA1967 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total KIAA1967 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Form/Format: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1.0 mg/ml (varies by lot)
• Sequence Length: 923

• Applicable Applications for anti-KIAA1967 antibody: Western Blot (WB)
• Application Notes: Western blotting: 1:500~1:3000
• Immunogen Type: Peptide
• Immunogen Description: Synthesized peptide derived from internal of human KIAA1967.
• Target Name: KIAA1967
• Preparation and Storage: Store at -20 degree C

Western Blot (WB)

(Western blot analysis of extracts from Jurkat cells, using KIAA1967 antibody.)

Related Product Information for anti-KIAA1967 antibody

Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis. Inhibits SUV39H1 methyltransferase activity. As part of a histone H3-specific methyltransferase complex may mediate ligand-dependent transcriptional activation by nuclear hormone receptors. Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress.Nagase T., DNA Res. 8:319-327(2001).Hamaguchi M., Proc. Natl. Acad. Sci. U.S.A. 99:13647-13652(2002).Olsen J.V., Cell 127:635-648(2006).

Product Categories/Family for anti-KIAA1967 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 24432106
• NCBI GeneID: 57805
• NCBI Accession #: NP_066997.3
• NCBI GenBank Nucleotide #: NM_021174.5
• UniProt Accession #: Q8N163; Q6P0Q9; Q8N3G7; Q8N8M1; Q8TF34; Q9H9Q9; Q9HD12; Q9NT55; A6NL03; B2RB79; D3DSR6
• Molecular Weight: 103,143 Da
• NCBI Official Full Name: cell cycle and apoptosis regulator protein 2
• NCBI Official Synonym Full Names: cell cycle and apoptosis regulator 2
• NCBI Official Symbol: CCAR2
• NCBI Official Synonym Symbols: DBC1; DBC-1; NET35; p30DBC; p30 DBC; KIAA1967
• NCBI Protein Information: cell cycle and apoptosis regulator protein 2
• UniProt Protein Name: Cell cycle and apoptosis regulator protein 2
• UniProt Gene Name: CCAR2
• UniProt Synonym Gene Names: DBC1; KIAA1967; DBC-1; DBC.1
• UniProt Entry Name: CCAR2_HUMAN

Uniprot Description

DBC-1: Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis. Inhibits SUV39H1 methyltransferase activity. Component of the DBIRD complex. Interacts with ZNF326/ZIRD; the interaction is direct. Interacts (via N-terminus) with SIRT1. Interacts (via N-terminus) with SUV39H1; this interaction abolishes the interaction with SIRT1. Expressed ubiquitously in normal tissues. Expressed in 84 to 100% of neoplastic breast, lung, and colon tissues. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear receptor co-regulator; Tumor suppressor; Mitochondrial; RNA-binding; Apoptosis

Chromosomal Location of Human Ortholog: 8p22

Cellular Component: nucleoplasm; spliceosome; mitochondrial matrix; cytoplasm; nuclear chromatin; nucleus

Molecular Function: enzyme inhibitor activity; protein binding; enzyme binding

Biological Process: positive regulation of apoptosis; RNA splicing; negative regulation of catalytic activity; rhythmic process; regulation of protein stability; mitochondrial fragmentation during apoptosis; cell cycle; regulation of circadian rhythm; mRNA processing; response to DNA damage stimulus; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; regulation of RNA elongation; response to UV