CKIP1 Blocking Peptide | PLEKHO1 blocking peptide

CKIP1 Peptide

Cat. Num. AAA152937

• Gene Names: PLEKHO1; OC120; CKIP-1
• Applications: Blocking (BL)
• Synonyms: CKIP1; CKIP1 Peptide; OC120; CKIP-1; HQ0024c; Pleckstrin homology domain-containing family O member 1; C-Jun-binding protein; PH domain-containing family O member 1; pleckstrin homology domain containing; family O member 1; PLEKHO1 blocking peptide

• Form/Format: Liquid
• Concentration: 200 ug/mL (varies by lot)
• Sequence Length: 409

• Applicable Applications for PLEKHO1 blocking peptide: Blocking (BL)
• Application Notes: CKIP1 peptide is used for blocking the activity of CKIP1 antibody.
• Species: Human
• Buffer: PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
• Location: 18 amino acids near the carboxy terminus of human CKIP1.
• Preparation and Storage: Store CKIP1 peptide at -20 degree C, stable for one year.

NCBI and Uniprot Product Information

• NCBI GI #: 20149626
• NCBI GeneID: 51177
• NCBI Accession #: NP_057358
• NCBI GenBank Nucleotide #: NM_016274.4
• UniProt Accession #: Q53GL0; Q336K5; Q8IZ51; Q9NRV3; Q9UL48
• Molecular Weight: 42,330 Da
• NCBI Official Full Name: pleckstrin homology domain-containing family O member 1
• NCBI Official Synonym Full Names: pleckstrin homology domain containing, family O member 1
• NCBI Official Symbol: PLEKHO1
• NCBI Official Synonym Symbols: OC120; CKIP-1
• NCBI Protein Information: pleckstrin homology domain-containing family O member 1; JBP; OC120; 2810052M02Rik; C-Jun-binding protein; CK2-interacting protein 1; casein kinase 2-interacting protein 1; PH domain-containing family O member 1; CK2 interacting protein 1; HQ0024c protein; osteoclast maturation-associated gene 120 protein
• UniProt Protein Name: Pleckstrin homology domain-containing family O member 1
• Protein Family: Pleckstrin homology domain-containing family
• UniProt Gene Name: PLEKHO1
• UniProt Synonym Gene Names: CKIP1; OC120; PH domain-containing family O member 1; JBP; CK2-interacting protein 1; CKIP-1
• UniProt Entry Name: PKHO1_HUMAN

Uniprot Description

PLEKHO1: Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Appears to also inhibit tumor cell growth by inhibiting AKT- mediated cell-survival. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Tumor suppressor; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 1q21.2

Cellular Component: cytoplasm; plasma membrane; nucleus

Molecular Function: protein binding