Rabbit NOC3L Polyclonal Antibody | anti-NOC3L antibody

NOC3L (F447) Polyclonal Antibody

Cat. Num. AAA3003672

• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: NOC3L; Polyclonal Antibody; NOC3L (F447) Polyclonal Antibody; Nucleolar complex protein 3 homolog; NOC3 protein homolog; Factor for adipocyte differentiation 24; NOC3-like protein; Nucleolar complex-associated protein 3-like protein; AD24; C10orf117; FAD24; anti-NOC3L antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: NOC3L (F447) polyclonal antibody detects endogenous levels of NOC3L protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 800

• Applicable Applications for anti-NOC3L antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:1000
• Immunogen: Synthetic peptide, corresponding to amino acids 417-436 of Human NOC3L.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of NOC3L (F447) pAb at 1:1000 dilutionLane1:HCT116 whole cell lysate (20ug) Lane2:HepG2 whole cell lysate (20ug) Lane3:AML-12 whole cell lysate (20ug) Lane4:H9C2 whole cell lysate (40ug))

Related Product Information for anti-NOC3L antibody

GADD 153, a growth arrest and DNA damage-inducible gene, encodes a C/EBP-related nuclear protein. This protein has also been designated C/EBP-homologous protein (CHOP-10 or C/EBP zeta). GADD 153 expression is induced by a variety of cellular stresses, inducing nutrient deprivation and metabolic perturbations. GADD 153 functions to block cells in G1 to S phase during cell cycle progression and acts by dimerizing with other C/EBP proteins to direct GADD 153 dimers away from "classical" C/EBP binding sites, recognizing instead unique "nonclassical" sites. Thus, GADD 153 acts as a negative modulator of C/EBP-like proteins in certain terminally differentiated cells. GADD 153 belongs to the CBF/MAK21 family, which also includes NOC2L, NOC3L and NOC4L. NOC3L, also designated factor for adipocyte differentiation 24 or Fad24, promotes adipogenesis by controlling DNA replication during the early stages of mitotic clonal expansion (MCE).

NCBI and Uniprot Product Information

• NCBI GI #: 20806097
• NCBI Accession #: NP_071896.8
• NCBI GenBank Nucleotide #: NP_071896.8
• UniProt Accession #: Q8WTT2
• Molecular Weight: ~ 93kDa
• NCBI Official Full Name: nucleolar complex protein 3 homolog
• UniProt Protein Name: Nucleolar complex protein 3 homolog
• Protein Family: Nucleolar complex protein
• UniProt Gene Name: NOC3L
• UniProt Synonym Gene Names: AD24; C10orf117; FAD24; NOC3 protein homolog
• UniProt Entry Name: NOC3L_HUMAN

Uniprot Description

NOC3L: May be required for adipogenesis. Belongs to the CBF/MAK21 family.

Protein type: RNA-binding; Nucleolus

Chromosomal Location of Human Ortholog: 10q23.33

Cellular Component: nucleolus; nuclear speck

Biological Process: fat cell differentiation