Testing Data
Mouse anti-Mouse CD72.1 Antibody | anti-CD72.1 antibody
Mouse Anti-Mouse CD72.1-PE
Reactivity
Mouse
Applications
Flow Cytometry, Functional Assay, Immunoprecipitation
Synonyms
CD72.1; Mouse Anti-Mouse CD72.1-PE; Lyb-2.1; CD72a; Lyb-2a; anti-CD72.1 antibody
Host
Mouse
Reactivity
Mouse
Isotype
IgG2bkappa
Clone Number
10.1.D2
Specificity
Mouse CD72.1
Form/Format
Supplied in PBS/NaN3 and a stabilizing agent
Concentration
0.1 mg/mL (varies by lot)
Applicable Applications for anti-CD72.1 antibody
Flow Cytometry (FC/FACS), Immunoprecipitation (IP), Activation, Blocking (BL), Costimulation
Volume
1.0 mL
Immunogen
DBA/2 mouse spleen cells
Conjugate
APC (Allophycocyanin)
Isotype Control
Mouse IgG2b-APC
Preparation and Storage
Store at 2-8 degree C.
Testing Data
Testing Data
Related Product Information for anti-CD72.1 antibody
Murine CD72.1 (Lyb-2.1), a type II integral membrane glycoprotein and a member of the C-lectin family of cell surface receptors, is a differentiation antigen of B cells and is found in mouse strains expressing the Lyb-2.1 allotype. CD72.1 is the ligand of CD5 which is distributed on all T cells and a small number of B cells. The 10.1.D2 monoclonal antibody blocks binding of CD5 to CD72 on the B cell surface which leads to inhibition of the positive signal resulting from CD5/CD72 pairing. However, 10.1.D2 can itself trigger a positive signal by binding CD72
References
1. Subbarao B, Mosier DE. Induction of B lymphocyte proliferation by monoclonal anti-Lyb 2 antibody. J Immunol. 1983;130:2033-7. (Immunogen, FC, Activ). 2. Robinson WH, Landolfi MM, Schäfer H, Parnes JR. Biochemical identity of the mouse Ly-19.2 and Ly-32.2 alloantigens with the B cell differentiation antigen Lyb-2/CD72. J Immunol. 1993;151:4764-72. (IP). 3. Snow EC, Mond JJ, Subbarao B. Enhancement by monoclonal anti-Lyb-2 antibody of antigen-specific B lymphocyte expansion stimulated by TNP-Ficoll and T lymphocyte-derived factors. J Immunol. 1986;137:1793-6. (Costim). 4. Robinson WH, Ying H, Miceli MC, Parnes JR. Extensive polymorphism in the extracellular domain of the mouse B cell differentiation antigen Lyb-2/CD72. J Immunol. 1992;149:880-6. (FC). 5. Luo W, van de Velde H, von Hoegen I, Parnes JR, Thielemans K. Ly-1 (CD5), a membrane glycoprotein of mouse T lymphocytes and a subset of B cells, is a natural ligand of the B cell surface protein Lyb-2 (CD72). J Immunol. 1992;148:1630-4. (Block, FC). 6. Zhu Z, Li R, Li H, Zhou T, Davis RS. FCRL5 exerts binary and compartment-specific influence on innate-like B-cell receptor signaling. Proc Natl Acad Sci USA. 2013;110:E1282-90. (FC)
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Product Notes
The CD72.1 (Catalog #AAA679283) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Mouse Anti-Mouse CD72.1-PE reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's CD72.1 can be used in a range of immunoassay formats including, but not limited to, Flow Cytometry (FC/FACS), Immunoprecipitation (IP), Activation, Blocking (BL), Costimulation. Researchers should empirically determine the suitability of the CD72.1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD72.1, Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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