Mouse MUCIN 5AC Monoclonal Antibody | anti-MUCIN 5AC antibody
MOUSE ANTI HUMAN MUCIN 5AC
Gene Names
MUC5AC; TBM; leB; MUC5
Applications
Immunohistochemistry, ELISA, Immunohistochemistry, Western Blot
Synonyms
MUCIN 5AC; Monoclonal Antibody; MOUSE ANTI HUMAN MUCIN 5AC; anti-MUCIN 5AC antibody
Host
Mouse
Clonality
Monoclonal
Isotype
IgG1
Clone Number
1-13M1
Specificity
This item is specific for the peptide core of gastric mucin (MUC5AC). This antibody has not been cross-adsorbed and may react with related peptides from other species. Mucins are high molecular weight glycoproteins that are found especially in the secretions of mucus membranes. Gastric Mucin 5AC antigen is found in columnar mucus cells of surface gastric epithelium and in goblet cells of the fetal and precancerous colon but not in normal colon. Resurgence of gastric mucin during colonic carcinogenesis is suggestive of either re-expression of the peptide core of gastric mucin in the adult colon or due to changes in the glycosylation pattern of mucin, which expose the hidden Mucin 5AC antigen.
Form/Format
Purified
Purified IgG - liquid
Purified IgG - liquid
Concentration
IgG concentration 0.1 mg/ml (varies by lot)
Sequence Length
5030
Applicable Applications for anti-MUCIN 5AC antibody
Immunohistology Frozen, ELISA (EIA), Immunohistology Paraffin*, Western Blot (WB)*
Application Notes
Immunohistology - Paraffin: Application Note: This product requires protein digestion pre-treatment of paraffin sections e.g. trypsin or pronase.
Western Blotting: Application Note: Clone 1-13M1 recognizes Mucin 5AC under non-reducing conditions.
Western Blotting: Application Note: Clone 1-13M1 recognizes Mucin 5AC under non-reducing conditions.
Perservative Stabilisers
0.05% Sodium Azide (NaN3)
Immunogen
A BALB/c mouse was immunized with mucin isolated from an ovarian cyst fluid (pure endocervical type according to the Fenoglio's classification).
Buffer Solution
Buffer Solution
Target Species
Human
Preparation and Storage
Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
Shelf Life: 18 months from date of despatch.
Related Product Information for anti-MUCIN 5AC antibody
MBS213391 is specific for the peptide core of gastric mucin (MUC5AC). This antibody has not been cross-adsorbed and may react with related peptides from other species. Mucins are high molecular weight glycoproteins that are found especially in the secretions of mucus membranes. Gastric Mucin 5AC antigen is found in columnar mucus cells of surface gastric epithelium and in goblet cells of the fetal and precancerous colon but not in normal colon. Resurgence of gastric mucin during colonic carcinogenesis is suggestive of either re-expression of the peptide core of gastric mucin in the adult colon or due to changes in the glycosylation pattern of mucin, which expose the hidden Mucin 5AC antigen.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
UniProt Accession #
Molecular Weight
526,608 Da
NCBI Official Full Name
Mucin-5AC
NCBI Official Synonym Full Names
mucin 5AC, oligomeric mucus/gel-forming
NCBI Official Symbol
MUC5AC
NCBI Official Synonym Symbols
TBM; leB; MUC5
NCBI Protein Information
mucin-5AC; gastric mucin; lewis B blood group antigen; major airway glycoprotein; mucin 5, subtypes A and C, tracheobronchial/gastric; mucin 5AC, oligomeric mucus/gel-forming pseudogene; mucin-5 subtype AC, tracheobronchial; tracheobronchial mucin
UniProt Protein Name
Mucin-5AC
UniProt Gene Name
MUC5AC
UniProt Synonym Gene Names
MUC5; MUC-5AC; LeB; TBM
UniProt Entry Name
MUC5A_HUMAN
Uniprot Description
MUC5AC iso1:
Chromosomal Location of Human Ortholog: 11p15.5
Cellular Component: Golgi lumen; fibril
Molecular Function: extracellular matrix structural constituent
Biological Process: protein amino acid O-linked glycosylation; cellular protein metabolic process; O-glycan processing; fibril organization and biogenesis; post-translational protein modification
Research Articles on MUCIN 5AC
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Product Notes
The MUCIN 5AC muc5ac (Catalog #AAA213391) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's MUCIN 5AC can be used in a range of immunoassay formats including, but not limited to, Immunohistology Frozen, ELISA (EIA), Immunohistology Paraffin*, Western Blot (WB)*. Immunohistology - Paraffin: Application Note: This product requires protein digestion pre-treatment of paraffin sections e.g. trypsin or pronase. Western Blotting: Application Note: Clone 1-13M1 recognizes Mucin 5AC under non-reducing conditions. Researchers should empirically determine the suitability of the MUCIN 5AC muc5ac for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MUCIN 5AC, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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